Versican

VCAN
Identifiers
Aliases	VCAN, CSPG2, ERVR, GHAP, PG-M, WGN, WGN1, versican
External IDs	OMIM: 118661 MGI: 102889 HomoloGene: 3228 GeneCards: VCAN
Gene location (Human)
Chr.	Chromosome 5 (human)
End	83,582,303 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	89,890,628 bp
RNA expression pattern
	Top expressed in
	monocyte; ; pericardium; ; right coronary artery; ; synovial joint; ; saphenous vein; ; spongy bone; ; ascending aorta; ; Achilles tendon; ; synovial membrane; ; visceral pleura;
	Top expressed in
	vas deferens; ; cumulus cell; ; semi-lunar valve; ; maxillary prominence; ; hand; ; dermis; ; molar; ; aortic valve; ; endocardial cushion; ; atrioventricular valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; glycosaminoglycan binding; protein binding; carbohydrate binding; extracellular matrix structural constituent; hyaluronic acid binding; extracellular matrix structural constituent conferring compression resistance;
Cellular component	membrane; extracellular matrix; lysosomal lumen; Golgi lumen; extracellular space; endoplasmic reticulum lumen; extracellular region; collagen-containing extracellular matrix; intracellular membrane-bounded organelle;
Biological process	glycosaminoglycan metabolic process; skeletal system development; cell recognition; chondroitin sulfate biosynthetic process; extracellular matrix organization; multicellular organism development; central nervous system development; cell adhesion; osteoblast differentiation; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; glial cell migration; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	1462
	13003
	ENSG00000038427
	ENSMUSG00000021614
	P13611; Q86W61
	Q62059
	NM_004385; NM_001126336; NM_001164097; NM_001164098
	NM_001081249; NM_001134474; NM_001134475; NM_019389; NM_172955
	NP_001119808; NP_001157569; NP_001157570; NP_004376; NP_001119808.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene.

Versican is a large chondroitin sulfate proteoglycan with an apparent molecular mass of more than 1000kDa. In 1989, Zimmermann and Ruoslahti cloned and sequenced the core protein of fibroblast chondroitin sulfate proteoglycan. They designated it versican in recognition of its versatile modular structure.

Versican belongs to the lectican protein family, with aggrecan (abundant in cartilage), brevican and neurocan (nervous system proteoglycans) as other members. Versican is also known as chondroitin sulfate proteoglycan core protein 2 or chondroitin sulfate proteoglycan 2 (CSPG2), and PG-M.

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