Aggrecan

ACAN
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4MD4
Identifiers
Aliases	ACAN, AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, Aggrecan, SSOAOD
External IDs	OMIM: 155760 HomoloGene: 136177 GeneCards: ACAN
Gene location (Human)
Chr.	Chromosome 15 (human)
End	88,875,353 bp
RNA expression pattern
	Top expressed in
	tibia; ; popliteal artery; ; ascending aorta; ; middle frontal gyrus; ; trachea; ; Achilles tendon; ; right coronary artery; ; periodontal fiber; ; spongy bone; ; pancreatic ductal cell;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent; metal ion binding; protein binding; hyaluronic acid binding; carbohydrate binding; extracellular matrix structural constituent conferring compression resistance;
Cellular component	extracellular matrix; extracellular region; lysosomal lumen; Golgi lumen; basement membrane; collagen-containing extracellular matrix; perisynaptic extracellular matrix; glutamatergic synapse; GABA-ergic synapse;
Biological process	skeletal system development; extracellular matrix disassembly; extracellular matrix organization; proteolysis; central nervous system development; keratan sulfate catabolic process; keratan sulfate biosynthetic process; cell adhesion; cartilage condensation; chondrocyte development; heart development; proteoglycan biosynthetic process; collagen fibril organization;
	Sources:Amigo / QuickGO
Orthologs
	176
	n/a
	ENSG00000157766
	n/a
	P16112
	n/a
	NM_001135; NM_013227; NM_001369268
	n/a
	NP_001126; NP_037359; NP_001356197
	n/a
	Wikidata
View/Edit Human

Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage.

Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing. Aggrecan was named for its ability to form large aggregates in the cartilage tissue (a large aggregating proteoglycan).

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