VEGF receptor

VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending on alternative splicing, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR).

VEGF receptor
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
Identifiers
SymbolVEGF
InterProIPR009135
Membranome1335
Identifiers
SymbolFLT1
Alt. symbolsFLT
NCBI gene2321
HGNC3763
OMIM165070
RefSeqNM_002019
UniProtP17948
Other data
EC number2.7.1.112
LocusChr. 13 q12
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StructuresSwiss-model
DomainsInterPro
kinase insert domain receptor (a type III receptor tyrosine kinase)
Identifiers
SymbolKDR
Alt. symbolsFLK1, VEGFR, VEGFR2, CD309
NCBI gene3791
HGNC6307
OMIM191306
RefSeqNM_002253
UniProtP35968
Other data
EC number2.7.1.112
LocusChr. 4 q11-q12
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StructuresSwiss-model
DomainsInterPro
fms-related tyrosine kinase 4
Identifiers
SymbolFLT4
Alt. symbolsVEGFR3, PCL
NCBI gene2324
HGNC3767
OMIM136352
RefSeqNM_002020
UniProtP35916
Other data
EC number2.7.1.112
LocusChr. 5 q34-q35
Search for
StructuresSwiss-model
DomainsInterPro

Inhibitors of VEGFR are used in the treatment of cancer.

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