Kinase insert domain receptor

KDR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1VR2, 1Y6A, 1Y6B, 1YWN, 2M59, 2MET, 2MEU, 2OH4, 2P2H, 2P2I, 2QU5, 2QU6, 2RL5, 2X1W, 2X1X, 2XIR, 3B8Q, 3B8R, 3BE2, 3C7Q, 3CJF, 3CJG, 3CP9, 3CPB, 3CPC, 3DTW, 3EFL, 3EWH, 3KVQ, 3S35, 3S36, 3S37, 3U6J, 3VHE, 3VHK, 3VID, 3VNT, 3VO3, 3WZD, 3WZE, 4AG8, 4AGC, 4AGD, 4ASD, 4ASE, 5EW3
Identifiers
Aliases	KDR, CD309, FLK1, VEGFR, VEGFR2, Kinase insert domain receptor
External IDs	OMIM: 191306 MGI: 96683 HomoloGene: 55639 GeneCards: KDR
Gene location (Human)
Chr.	Chromosome 4 (human)
End	55,125,595 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	76,139,118 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; lower lobe of lung; ; parietal pleura; ; pericardium; ; right lobe of thyroid gland; ; right lung; ; left lobe of thyroid gland; ; upper lobe of lung; ; visceral pleura; ; upper lobe of left lung;
	Top expressed in
	vein; ; left lung; ; left lung lobe; ; right lung; ; right lung lobe; ; ankle joint; ; cardiac muscles; ; vascular endothelium; ; brown adipose tissue; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; Hsp90 protein binding; nucleotide binding; protein kinase activity; growth factor binding; vascular endothelial growth factor binding; kinase activity; integrin binding; protein binding; ATP binding; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity; protein tyrosine kinase activity; identical protein binding; receptor tyrosine kinase; transmembrane signaling receptor activity; cadherin binding;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; membrane; integral component of plasma membrane; extracellular region; cell junction; early endosome; membrane raft; sorting endosome; cytoplasmic vesicle; nucleus; endosome; plasma membrane; endoplasmic reticulum; receptor complex;
Biological process	negative regulation of endothelial cell apoptotic process; cell differentiation; positive regulation of protein phosphorylation; positive regulation of mitochondrial fission; positive regulation of endothelial cell proliferation; phosphorylation; extracellular matrix organization; negative regulation of apoptotic process; positive regulation of nitric-oxide synthase biosynthetic process; cell migration involved in sprouting angiogenesis; positive regulation of angiogenesis; vasculogenesis; positive regulation of endothelial cell migration; multicellular organism development; protein phosphorylation; positive regulation of macroautophagy; positive regulation of mitochondrial depolarization; positive regulation of vasculogenesis; embryonic hemopoiesis; endothelium development; regulation of cell shape; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; peptidyl-tyrosine autophosphorylation; protein autophosphorylation; positive regulation of focal adhesion assembly; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; cellular response to vascular endothelial growth factor stimulus; viral process; calcium-mediated signaling using intracellular calcium source; positive regulation of MAPK cascade; positive regulation of positive chemotaxis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; positive regulation of cell population proliferation; angiogenesis; positive regulation of cell migration; protein kinase B signaling; ERK1 and ERK2 cascade; negative regulation of gene expression; positive regulation of blood vessel endothelial cell migration; cellular response to hydrogen sulfide; positive regulation of cell migration involved in sprouting angiogenesis; negative regulation of signal transduction; sprouting angiogenesis; cell migration; endothelial cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3791
	16542
	ENSG00000128052
	ENSMUSG00000062960
	P35968
	P35918; Q8VCD0
	NM_002253
	NM_010612; NM_001363216
	NP_002244
	NP_034742; NP_001350145
	Wikidata
View/Edit Human	View/Edit Mouse

Kinase insert domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309 (cluster of differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).

The Q472H germline KDR genetic variant affects VEGFR-2 phosphorylation and has been found to associate with microvessel density in NSCLC.

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