CD137

TNFRSF9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D0J
Identifiers
Aliases	TNFRSF9, 4-1BB, CD137, CDw137, ILA, tumor necrosis factor receptor superfamily member 9, TNF receptor superfamily member 9
External IDs	OMIM: 602250 MGI: 1101059 HomoloGene: 1199 GeneCards: TNFRSF9
Gene location (Human)
Chr.	Chromosome 1 (human)
End	7,943,165 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	151,030,559 bp
RNA expression pattern
	Top expressed in
	lymph node; ; blood; ; appendix; ; monocyte; ; gallbladder; ; thymus; ; thymus; ; pancreatic ductal cell; ; spleen; ; rectum;
	Top expressed in
	thymus; ; lymph node; ; islet of Langerhans; ; uterus; ; morula; ; blood; ; spleen; ; subcutaneous adipose tissue; ; body of femur; ; Region I of hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine binding; tumor necrosis factor-activated receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; external side of plasma membrane; extracellular space; plasma membrane;
Biological process	multicellular organism development; regulation of apoptotic process; response to lipopolysaccharide; inflammatory response; immune response; protein homotrimerization; apoptotic process; negative regulation of cell population proliferation; tumor necrosis factor-mediated signaling pathway; regulation of cell population proliferation; apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3604
	21942
	ENSG00000049249
	ENSMUSG00000028965
	Q07011
	P20334
	NM_001561
	NM_001077508; NM_001077509; NM_011612
	NP_001552
	NP_001070976; NP_001070977; NP_035742
	Wikidata
View/Edit Human	View/Edit Mouse

CD137, a member of the tumor necrosis factor (TNF) receptor family, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB, and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule, and as a potential target in cancer immunotherapy.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.