Tumor necrosis factor superfamily

The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine. These proteins are expressed predominantly by immune cells and they regulate diverse cell functions, including immune response and inflammation, but also proliferation, differentiation, apoptosis and embryogenesis.

Tumor necrosis factor superfamily
Trimeric structure of TNF alpha, produced by Mus musculus, based on PDB structure 2TNF (1.4 Å Resolution). Different colors represent different monomers. Baeyens, KJ et al. (1999). Figure rendered using FirstGlance Jmol.
Identifiers
SymbolTNF
PfamPF00229
InterProIPR006052
PROSITEPDOC00224
SCOP21tnf / SCOPe / SUPFAM
OPM superfamily292
OPM protein2hew
Membranome80
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
TNF
crystal structure of trail-sdr5
Identifiers
SymbolTNF
PfamPF00229
Pfam clanCL0100
InterProIPR006052
PROSITEPDOC00561
SCOP21tnr / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The superfamily contains 19 members that bind to 29 members of TNF receptor superfamily. An occurrence of orthologs in invertebrates hints at ancient origin of this superfamily in evolution.

The PROSITE pattern of this superfamily is located in a beta sheet in the central section of the protein that is conserved across all members.

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