U.S. Route 22

U.S. Route 22
U.S. Route 22
Route information
Length	648.84 mi (1,044.21 km)
Existed	1926–present
Major junctions
West end	US 27 / US 42 / US 52 / US 127 in Cincinnati, OH
	I-70 near Zanesville, OH; I-77 near Cambridge, OH; I-79 in Collier Township, PA; I-76 / I-376 / Penna Turnpike in Monroeville, PA (I-376 and US 22 are concurrent from Robinson Township to Monroeville); I-99 in Hollidaysburg, PA; I-81 / I-83 near Harrisburg, PA; I-78 from Union Township to Fogelsville, PA; I-476 / Penna Turnpike NE Extension near Allentown, PA; I-78 from Alpha to Clinton, NJ; G.S. Parkway in Union Township, NJ;
East end	I-78 / US 1-9 in Newark, NJ
Location
Country	United States
States	Ohio, West Virginia, Pennsylvania, New Jersey
Highway system
	United States Numbered Highway System; List; Special; Divided;

U.S. Route 22 (US 22) is a major west–east route and one of the original United States Numbered Highways, founded in 1926. It runs from Cincinnati, Ohio, at US 27, US 42, US 127, and US 52 to Newark, New Jersey, at US 1/9 at the Newark Airport Interchange.

US 22 is named the William Penn Highway through most of Pennsylvania. In southwest Ohio, it overlaps with State Route 3 (SR 3) and is familiarly known as the 3-C Highway, "22 and 3", and Montgomery Road.

A section of US 22 in Pennsylvania between New Alexandria at US 119 and Harrisburg at Interstate 81 (I-81) has been designated a part of Corridor M of the Appalachian Development Highway System.

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