U.S. Route 221 in Florida

U.S. Highway 221
U.S. Highway 221
	US 221 highlighted in red
Route information
	Maintained by FDOT
Length	39.978 mi (64.338 km)
Existed	1930–present
Major junctions
South end	; US 19 / US 27 Alt. / US 98 in Perry;
	US 27 in Perry; CR 14 at Shady Grove; I-10 near Greenville; US 90 in Greenville;
North end	US 221 / SR 76 towards Quitman, GA
Location
Country	United States
State	Florida
Counties	Taylor, Madison, Jefferson
Highway system
	United States Numbered Highway System; List; Special; Divided; Florida State Highway System; Interstate; US; State Former; Pre‑1945; ; Toll; Scenic;

U.S. Route 221 (US 221) in Florida is a north–south United States Highway. It runs 40 miles (64 km) from Perry northwest to the Georgia State Line in Taylor, Madison and Jefferson Counties. The entire route is inventoried by FDOT as the northern section of unsigned State Road 55. A short overlap with US 90 exists in Greenville.

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