U.S. Route 221

U.S. Route 221
U.S. Route 221
	US 221 highlighted in red
Route information
Length	734 mi (1,181 km)
Existed	1930–present
Major junctions
South end	; US 19 / US 27 Alt. / US 98 / SR 55 in Perry, FL;
	I-10 near Greenville, FL; I-75 in Valdosta, GA; I-16 near Soperton, GA; I-20 near Harlem, GA; I-385 near Laurens, SC; I-26 in Roebuck, SC; I-85 in Spartanburg, SC; I-40 in Marion, NC; I-77 near Hillsville, VA; I-581 in Roanoke, VA;
North end	; ; ; US 29 Bus. / US 460 Bus. / US 501 Bus. at Lynchburg, VA;
Location
Country	United States
States	Florida, Georgia, South Carolina, North Carolina, Virginia
Highway system
	United States Numbered Highway System; List; Special; Divided;

U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg, Virginia, at US 29 Business (Lynchburg Expressway). It travels through the states of Florida, Georgia, South Carolina, North Carolina, and Virginia. It travels through the cities of Valdosta, Georgia; Spartanburg, South Carolina; Marion, North Carolina; Roanoke, Virginia; and Lynchburg, Virginia.

Throughout western North Carolina, from the Virginia state line to the Blue Ridge Parkway, US 221 is a challenging drive, and can be described as one climb after another. In some places, the route skirts around large foothills.

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