Tryptophan hydroxylase
Tryptophan hydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the monoamine neurotransmitter serotonin. Tyrosine hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase together constitute the family of biopterin-dependent aromatic amino acid hydroxylases. TPH catalyzes the following chemical reaction
- L-tryptophan + tetrahydrobiopterin + O2 5-Hydroxytryptophan + dihydrobiopterin + H2O
| tryptophan 5-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
tryptophan 5-monooxygenase monomer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 1.14.16.4 | ||||||||
| CAS no. | 9037-21-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TPH1 | ||||||
| Alt. symbols | TPRH, TPH | ||||||
| NCBI gene | 7166 | ||||||
| HGNC | 12008 | ||||||
| OMIM | 191060 | ||||||
| PDB | 1MLW | ||||||
| RefSeq | NM_004179 | ||||||
| UniProt | P17752 | ||||||
| Other data | |||||||
| EC number | 1.14.16.4 | ||||||
| Locus | Chr. 11 p15.3-p14 | ||||||
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| tryptophan hydroxylase 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TPH2 | ||||||
| NCBI gene | 121278 | ||||||
| HGNC | 20692 | ||||||
| OMIM | 607478 | ||||||
| RefSeq | NM_173353 | ||||||
| UniProt | Q8IWU9 | ||||||
| Other data | |||||||
| Locus | Chr. 12 q15 | ||||||
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