TPH1

TPH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MLW, 3HF6, 3HF8, 3HFB, 5J6D
Identifiers
Aliases	TPH1, TPRH, TRPH, tryptophan hydroxylase 1
External IDs	OMIM: 191060 MGI: 98796 HomoloGene: 121565 GeneCards: TPH1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	18,046,269 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	46,321,961 bp
RNA expression pattern
	Top expressed in
	rectum; ; ascending aorta; ; pylorus; ; jejunal mucosa; ; duodenum; ; body of stomach; ; anterior pituitary; ; transverse colon; ; pineal gland; ; gastric mucosa;
	Top expressed in
	pineal gland; ; duodenum; ; pyloric antrum; ; jejunum; ; left colon; ; extraocular muscle; ; carotid body; ; lip; ; dermis; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; metal ion binding; monooxygenase activity; tryptophan 5-monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; oxidoreductase activity;
Cellular component	cytoplasm; cytosol; neuron projection;
Biological process	response to immobilization stress; mammary gland alveolus development; serotonin biosynthetic process; negative regulation of ossification; aromatic amino acid family metabolic process; bone remodeling; circadian rhythm; positive regulation of fat cell differentiation; indolalkylamine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	7166
	21990
	ENSG00000129167
	ENSMUSG00000040046
	P17752
	P17532
	NM_004179
	NM_001136084; NM_001276372; NM_009414
	NP_004170
	NP_001129556; NP_001263301; NP_033440
	Wikidata
View/Edit Human	View/Edit Mouse

Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the TPH1 gene.

TPH1 was first discovered to support serotonin synthesis in 1988 by converting tryptophan into 5-hydroxytryptophan. It was thought that there only was a single TPH gene until 2003. A second form was found in the mouse (Tph2), rat and human brain (TPH2) and the original TPH was then renamed to TPH1.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.