Tropomyosin receptor kinase C

Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene.

NTRK3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNTRK3, GP145-TrkC, TRKC, gp145(trkC), neurotrophic receptor tyrosine kinase 3
External IDsOMIM: 191316 MGI: 97385 HomoloGene: 49183 GeneCards: NTRK3
Orthologs
SpeciesHumanMouse
Entrez

4916

18213

Ensembl

ENSG00000140538

ENSMUSG00000059146

UniProt

Q16288

Q6VNS1

RefSeq (mRNA)

NM_008746
NM_182809

RefSeq (protein)

NP_032772
NP_877961

Location (UCSC)Chr 15: 87.86 – 88.26 MbChr 7: 78.18 – 78.74 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). As such, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival.

The TrkC receptor is part of the large family of receptor tyrosine kinases. A "tyrosine kinase" is an enzyme which is capable of adding a phosphate group to the certain tyrosines on target proteins, or "substrates". A receptor tyrosine kinase is a "tyrosine kinase" which is located at the cellular membrane, and is activated by binding of a ligand via its extracellular domain. Other example of tyrosine kinase receptors include the insulin receptor, the IGF-1 receptor, the MuSK protein receptor, the vascular endothelial growth factor (VEGF) receptor, etc. The "substrate" proteins which are phosphorylated by TrkC include PI3 kinase.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.