Neurotrophin-3

NTF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B8K, 1BND, 1NT3, 3BUK
Identifiers
Aliases	NTF3, HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 3
External IDs	OMIM: 162660 MGI: 97380 HomoloGene: 1896 GeneCards: NTF3
Gene location (Human)
Chr.	Chromosome 12 (human)
End	5,521,536 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	126,143,873 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; right coronary artery; ; ascending aorta; ; left coronary artery; ; saphenous vein; ; right lobe of liver; ; gastric mucosa; ; canal of the cervix; ; vagina; ; cerebellar hemisphere;
	Top expressed in
	ciliary body; ; ascending aorta; ; iris; ; corneal stroma; ; conjunctival fornix; ; maxillary prominence; ; substantia nigra; ; pineal gland; ; medullary collecting duct; ; semi-lunar valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neurotrophin p75 receptor binding; neurotrophin receptor binding; chemoattractant activity; growth factor activity; signaling receptor binding; protein binding;
Cellular component	cytoplasmic vesicle; extracellular region; extracellular space; synaptic vesicle; axon; dendrite;
Biological process	regulation of apoptotic process; negative regulation of neuron apoptotic process; regulation of neuron differentiation; activation of protein kinase B activity; neuron projection morphogenesis; activation of GTPase activity; positive regulation of receptor internalization; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; cell-cell signaling; positive regulation of peptidyl-serine phosphorylation; induction of positive chemotaxis; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin cytoskeleton reorganization; signal transduction; positive chemotaxis; nervous system development; regulation of signaling receptor activity; positive regulation of phospholipase C activity; positive regulation of phosphatidylinositol 3-kinase signaling; peripheral nervous system development; memory; nerve development; nerve growth factor signaling pathway; modulation of chemical synaptic transmission; positive regulation of neurotrophin TRK receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4908
	18205
	ENSG00000185652
	ENSMUSG00000049107
	P20783
	P20181
	NM_001102654; NM_002527
	NM_001164034; NM_001164035; NM_008742
	NP_001096124; NP_002518
	NP_001157506; NP_001157507; NP_032768
	Wikidata
View/Edit Human	View/Edit Mouse

Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.

The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic Factor).

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.