Tropomyosin receptor kinase A

NTRK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS
Identifiers
Aliases	NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1
External IDs	OMIM: 191315 MGI: 97383 HomoloGene: 1898 GeneCards: NTRK1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,881,850 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	87,702,469 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; left uterine tube; ; pons; ; left ventricle; ; trigeminal ganglion; ; putamen; ; canal of the cervix; ; right adrenal gland; ; caudate nucleus; ; anterior pituitary;
	Top expressed in
	superior cervical ganglion; ; neural tube; ; trigeminal ganglion; ; superior ganglion of vagus nerve; ; superior frontal gyrus; ; stellate ganglion; ; superior ganglion of glossopharyngeal nerve; ; meninges; ; Greater petrosal nerve; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neurotrophin binding; GPI-linked ephrin receptor activity; neurotrophin receptor activity; kinase activity; ATP binding; protein kinase activity; kinase binding; transferase activity; protein homodimerization activity; protein binding; nucleotide binding; nerve growth factor binding; neurotrophin p75 receptor binding; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; nerve growth factor receptor activity;
Cellular component	cytoplasm; endosome; membrane; late endosome membrane; cell surface; integral component of membrane; late endosome; early endosome membrane; receptor complex; plasma membrane; axon; neuronal cell body; early endosome; integral component of plasma membrane; dendrite; cytoplasmic vesicle; Golgi membrane; endosome membrane; protein-containing complex; recycling endosome; recycling endosome membrane;
Biological process	negative regulation of neuron apoptotic process; positive regulation of protein phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of programmed cell death; behavioral response to formalin induced pain; detection of temperature stimulus involved in sensory perception of pain; protein phosphorylation; circadian rhythm; positive regulation of ERK1 and ERK2 cascade; B cell differentiation; response to ethanol; innervation; negative regulation of cell population proliferation; response to nicotine; positive regulation of GTPase activity; positive regulation of synaptic transmission, glutamatergic; response to nutrient levels; learning or memory; protein autophosphorylation; negative regulation of neuron death; detection of mechanical stimulus involved in sensory perception of pain; cell differentiation; neurotrophin TRK receptor signaling pathway; phosphorylation; cellular response to nicotine; olfactory nerve development; response to electrical stimulus; Sertoli cell development; mechanoreceptor differentiation; nervous system development; positive regulation of angiogenesis; positive regulation of NF-kappaB transcription factor activity; response to axon injury; sensory perception of pain; response to radiation; phosphatidylinositol-mediated signaling; sympathetic nervous system development; ephrin receptor signaling pathway; cellular response to growth factor stimulus; human ageing; response to hydrostatic pressure; response to activity; axon guidance; multicellular organism development; axonogenesis involved in innervation; positive regulation of neuron projection development; programmed cell death involved in cell development; positive regulation of synapse assembly; transmembrane receptor protein tyrosine kinase signaling pathway; microtubule-based movement; peptidyl-tyrosine phosphorylation; peptidyl-tyrosine autophosphorylation; nerve growth factor signaling pathway; cellular response to nerve growth factor stimulus; positive regulation of phosphatidylinositol 3-kinase signaling; negative regulation of apoptotic process; regulation of MAPK cascade; positive regulation of MAPK cascade; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	4914
	18211
	ENSG00000198400
	ENSMUSG00000028072
	P04629
	Q3UFB7
	NM_002529; NM_001007792; NM_001012331
	NM_001033124
	NP_001007793; NP_001012331; NP_002520
	NP_001028296
	Wikidata
View/Edit Human	View/Edit Mouse

Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene.

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself (autophosphorylation) and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behaviors, intellectual disability and/or cognitive impairment and certain cancers. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

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