Congenital insensitivity to pain with anhidrosis
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder of the nervous system which prevents the feeling of pain or temperature, and prevents a person from sweating. Cognitive disorders are commonly coincident. CIPA is the fourth type of hereditary sensory and autonomic neuropathy (HSAN), and is also known as HSAN IV.
| Congenital insensitivity to pain with anhidrosis | |
|---|---|
| Charcot joints are shown in this boy with CIPA. | |
| Causes | Genetic mutations |
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