Tisotumab vedotin
Tisotumab vedotin, sold under the brand name Tivdak, is an antibody-drug conjugate used to treat cervical cancer. It is a combination of tisotumab, a monoclonal antibody against tissue factor, and monomethyl auristatin E (MMAE), a potent inhibitor of cell division. It is administered by infusion into a vein.
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | Tissue factor (TF) |
| Clinical data | |
| Trade names | Tivdak |
| Other names | Tisotumab vedotin-tftv |
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| Routes of administration | Intravenous |
| Drug class | Antineoplastic |
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| Pharmacokinetic data | |
| Protein binding | 68–82% (MMAE) |
| Metabolism | Hepatic, by CYP3A4 (MMAE) |
| Metabolites | MMAE |
| Elimination half-life | 4 days |
| Excretion | Fecal, renal (MMAE) |
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Tisotumab vedotin was approved for medical use in the United States in September 2021. The U.S. Food and Drug Administration considers it to be a first-in-class medication.
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