Ticagrelor

Ticagrelor
Clinical data
Trade names	Brilinta, Brilique, others
Other names	AZD-6140
AHFS/Drugs.com	Monograph
MedlinePlus	a611050
License data	EU EMA: by INN; US DailyMed: Ticagrelor; US FDA: Ticagrelor;
Pregnancy; category	AU: B1;
Routes of; administration	By mouth
ATC code	B01AC24 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: WARNINGRx-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	36%
Protein binding	>99.7%
Metabolism	Liver (CYP3A4)
Elimination half-life	7 hrs (ticagrelor), 8.5 hrs (active metabolite AR-C124910XX)
Excretion	Bile duct
Identifiers
	IUPAC name (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino]-5-(propylthio)- 3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol;
CAS Number	274693-27-5 ;
PubChem CID	9871419;
IUPHAR/BPS	1765;
DrugBank	DB08816 ;
ChemSpider	8047109 ;
UNII	GLH0314RVC;
KEGG	D09017 ;
ChEMBL	ChEMBL398435 ;
CompTox Dashboard (EPA)	DTXSID901009337 ;
ECHA InfoCard	100.114.746
Chemical and physical data
Formula	C23H28F2N6O4S
Molar mass	522.57 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(F)c(F)c2)c2nnn([C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)c2n1;
	InChI InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1 ; Key:OEKWJQXRCDYSHL-FNOIDJSQSA-N ;
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Ticagrelor, sold under the brand name Brilinta among others, is a medication used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y₁₂ receptor. The drug is produced by AstraZeneca.

The most common side effects include dyspnea (difficulty breathing), bleeding and raised uric acid level in the blood.

It was approved for medical use in the European Union in December 2010, and in the United States in July 2011. In 2020, it was the 247th most commonly prescribed medication in the United States, with more than 1 million prescriptions.

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