P2Y₁₂

P2RY12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NTJ, 4PXZ, 4PY0
Identifiers
Aliases	P2RY12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999, purinergic receptor P2Y12
External IDs	OMIM: 600515 MGI: 1918089 HomoloGene: 11260 GeneCards: P2RY12
Gene location (Human)
Chr.	Chromosome 3 (human)
End	151,384,753 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	59,170,292 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; superior vestibular nucleus; ; ventral tegmental area; ; subthalamic nucleus; ; Brodmann area 46; ; monocyte; ; corpus callosum; ; spinal ganglia; ; spinal cord; ; substantia nigra;
	Top expressed in
	globus pallidus; ; blood; ; superior frontal gyrus; ; morula; ; optic nerve; ; olfactory tubercle; ; Region I of hippocampus proper; ; primary motor cortex; ; hippocampus proper; ; carotid body;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled adenosine receptor activity; G protein-coupled receptor activity; guanyl-nucleotide exchange factor activity; G protein-coupled purinergic nucleotide receptor activity; signal transducer activity; G protein-coupled ADP receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; cell surface; basal plasma membrane; mitochondrion; caveola; intrinsic component of membrane; external side of plasma membrane;
Biological process	hemostasis; G protein-coupled adenosine receptor signaling pathway; regulation of calcium ion transport; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; protein kinase B signaling; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; negative regulation of cell differentiation; substrate-dependent cell migration, cell extension; cellular response to organic cyclic compound; negative regulation of norepinephrine secretion; G protein-coupled purinergic nucleotide receptor signaling pathway; regulation of microglial cell migration; cell projection organization; calcium ion transmembrane transport; positive regulation of ion transport; potassium ion transmembrane transport; cellular response to ATP; platelet aggregation; glial cell migration; signal transduction; blood coagulation; platelet activation; G protein-coupled receptor signaling pathway; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	64805
	70839
	ENSG00000169313
	ENSMUSG00000036353
	Q9H244
	Q9CPV9
	NM_176876; NM_022788
	NM_027571; NM_001357007; NM_001357008; NM_001357010
	NP_073625; NP_795345
	NP_081847; NP_001343936; NP_001343937; NP_001343939
	Wikidata
View/Edit Human	View/Edit Mouse

P2Y₁₂ is a chemoreceptor for adenosine diphosphate (ADP) that belongs to the G_i class of a group of G protein-coupled (GPCR) purinergic receptors. This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. The P2Y₁₂ receptor is involved in platelet aggregation and is thus a biological target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

In the field of purinergic signaling, the P2Y₁₂ protein on the periphery is found mainly but not exclusively on the surface of blood platelets, and is an important regulator in blood clotting. In the central nervous system, this receptor has been found expressed exclusively on microglia, where it is necessary for physiological and pathological microglial actions, such as monitoring neuronal functions and microglial neuroprotection.

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P2Y12

P2Y₁₂