Sex-determining region Y protein

SRY
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HRY, 1HRZ, 1J46, 1J47, 2GZK
Identifiers
Aliases	SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y
External IDs	OMIM: 480000 MGI: 98660 HomoloGene: 48168 GeneCards: SRY
Gene location (Human)
Chr.	Y chromosome (human)
End	2,787,682 bp
Gene location (Mouse)
Chr.	Y chromosome (mouse)
End	2,663,658 bp
RNA expression pattern
	Top expressed in
	gonad; ; skin of abdomen; ; islet of Langerhans; ; Achilles tendon; ; ganglionic eminence; ; pharynx; ; thymus; ; placenta; ; subcutaneous adipose tissue; ; mammary gland;
	Top expressed in
	ankle joint; ; ascending aorta; ; aortic valve; ; cumulus cell; ; supraoptic nucleus; ; salivary gland; ; condyle; ; lacrimal gland; ; major salivary gland; ; stria vascularis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; transcription factor binding; calmodulin binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nuclear speck; nucleoplasm; nucleus;
Biological process	cell differentiation; regulation of transcription, DNA-templated; sex differentiation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of male gonad development; male sex determination; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; central nervous system development; positive regulation of gene expression; neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	6736
	21674
	ENSG00000184895
	ENSMUSG00000069036
	Q05066
	Q05738
	NM_003140
	NM_011564
	NP_003131
	NP_035694
	Wikidata
View/Edit Human	View/Edit Mouse

Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placental mammals and marsupials). SRY is an intronless sex-determining gene on the Y chromosome. Mutations in this gene lead to a range of disorders of sex development with varying effects on an individual's phenotype and genotype.

SRY is a member of the SOX (SRY-like box) gene family of DNA-binding proteins. When complexed with the (SF-1) protein, SRY acts as a transcription factor that causes upregulation of other transcription factors, most importantly SOX9. Its expression causes the development of primary sex cords, which later develop into seminiferous tubules. These cords form in the central part of the yet-undifferentiated gonad, turning it into a testis. The now-induced Leydig cells of the testis then start secreting testosterone, while the Sertoli cells produce anti-Müllerian hormone. SRY gene effects normally take place 6–8 weeks after fetus formation which inhibits the female anatomical structural growth in males. It also works towards developing the secondary sexual characteristics of males.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.