Steroidogenic factor 1

NR5A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YOW, 1ZDT, 4QJR, 4QK4
Identifiers
Aliases	NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3, hSF-1, nuclear receptor subfamily 5 group A member 1, SRXX4
External IDs	OMIM: 184757 MGI: 1346833 HomoloGene: 3638 GeneCards: NR5A1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	124,507,420 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	38,604,554 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; spleen; ; anterior pituitary; ; left uterine tube; ; monocyte; ; hypothalamus; ; blood; ; placenta; ; cecum; ; lymph node;
	Top expressed in
	adrenal gland; ; Leydig cell; ; entorhinal cortex; ; cumulus cell; ; Sertoli cell; ; extraocular muscle; ; urethra; ; male urethra; ; soleus muscle; ; adrenal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; zinc ion binding; lipid binding; double-stranded DNA binding; enzyme binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; steroid hormone receptor activity; transcription coactivator activity; phospholipid binding; metal ion binding; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; chromatin binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; nuclear receptor activity; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding;
Cellular component	nucleoplasm; RNA polymerase II transcription regulator complex; nucleus;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of steroid biosynthetic process; hormone metabolic process; luteinization; reproductive process; primary sex determination; tissue development; multicellular organism aging; cell differentiation; maintenance of protein location in nucleus; regulation of transcription, DNA-templated; adrenal gland development; transcription, DNA-templated; steroid hormone mediated signaling pathway; cell-cell signaling; transcription by RNA polymerase II; negative regulation of female gonad development; transcription initiation from RNA polymerase II promoter; positive regulation of male gonad development; intracellular receptor signaling pathway; positive regulation of transcription by RNA polymerase II; sex-determination system; male gonad development; female gonad development; positive regulation of gene expression; hormone-mediated signaling pathway; calcineurin-mediated signaling; response to gonadotropin-releasing hormone; male sex determination;
	Sources:Amigo / QuickGO
Orthologs
	2516
	26423
	ENSG00000136931
	ENSMUSG00000026751
	Q13285
	P33242
	NM_004959
	NM_139051; NM_001316687
	NP_004950; NP_004950.2
	NP_001303616; NP_620639
	Wikidata
View/Edit Human	View/Edit Mouse

The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling the activity of genes related to the reproductive glands or gonads and adrenal glands. This protein is encoded by the NR5A1 gene, a member of the nuclear receptor subfamily, located on the long arm of chromosome 9 at position 33.3. It was originally identified as a regulator of genes encoding cytochrome P450 steroid hydroxylases, however, further roles in endocrine function have since been discovered.

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