Telomerase reverse transcriptase

TERT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BCK, 4B18, 4MNQ
Identifiers
Aliases	TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, HTERT
External IDs	OMIM: 187270 MGI: 1202709 HomoloGene: 31141 GeneCards: TERT
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,295,068 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,797,962 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; thymus; ; cardia; ; tongue; ; vein; ; external globus pallidus; ; pylorus; ; superior surface of tongue; ; saphenous vein; ; pericardium;
	Top expressed in
	Paneth cell; ; secondary oocyte; ; medullary collecting duct; ; condyle; ; fossa; ; trigeminal ganglion; ; morula; ; yolk sac; ; ganglionic eminence; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; telomeric DNA binding; tRNA binding; metal ion binding; RNA-directed 5'-3' RNA polymerase activity; telomerase RNA reverse transcriptase activity; protein binding; transcription coactivator binding; telomerase RNA binding; telomerase activity; protein homodimerization activity; chaperone binding; template-free RNA nucleotidyltransferase; RNA binding; protein C-terminus binding; protein N-terminus binding; identical protein binding; reverse transcriptase; RNA-directed DNA polymerase activity;
Cellular component	cytoplasm; PML body; nuclear telomere cap complex; RNA-directed RNA polymerase complex; nucleoplasm; chromosome; telomere; telomerase catalytic core complex; nucleolus; mitochondrion; TERT-RMRP complex; mitochondrial nucleoid; nucleus; plasma membrane; telomerase holoenzyme complex; cytosol; nuclear speck;
Biological process	positive regulation of protein localization to nucleolus; telomere maintenance via telomerase; DNA biosynthetic process; regulation of protein stability; replicative senescence; RNA-dependent DNA biosynthetic process; mitochondrion organization; negative regulation of gene expression; transcription, RNA-templated; positive regulation of Wnt signaling pathway; production of siRNA involved in RNA interference; positive regulation of nitric-oxide synthase activity; establishment of protein localization to telomere; negative regulation of production of siRNA involved in RNA interference; DNA strand elongation; positive regulation of protein binding; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; telomere maintenance; RNA biosynthetic process; positive regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of cellular senescence; response to cadmium ion; positive regulation of G1/S transition of mitotic cell cycle; beta-catenin-TCF complex assembly; negative regulation of apoptotic process; positive regulation of glucose import; positive regulation of angiogenesis; positive regulation of vascular associated smooth muscle cell migration; negative regulation of glial cell proliferation; positive regulation of transdifferentiation; cellular response to hypoxia; positive regulation of vascular associated smooth muscle cell proliferation; negative regulation of endothelial cell apoptotic process; negative regulation of neuron apoptotic process; positive regulation of hair cycle; positive regulation of stem cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	7015
	21752
	ENSG00000164362
	ENSMUSG00000021611
	O14746
	O70372
	NM_001193376; NM_198253; NM_198254; NM_198255
	NM_009354; NM_001362387; NM_001362388
	NP_001180305; NP_937983
	NP_033380; NP_001349316; NP_001349317
	Wikidata
View/Edit Human	View/Edit Mouse

Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.

Telomerases are part of a distinct subgroup of RNA-dependent polymerases. Telomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise become postmitotic and undergo apoptosis to exceed the Hayflick limit and become potentially immortal, as is often the case with cancerous cells. To be specific, TERT is responsible for catalyzing the addition of nucleotides in a TTAGGG sequence to the ends of a chromosome's telomeres. This addition of repetitive DNA sequences prevents degradation of the chromosomal ends following multiple rounds of replication.

hTERT absence (usually as a result of a chromosomal mutation) is associated with the disorder Cri du chat.

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