Tyrosine kinase 2

TYK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LXN, 3LXP, 3NYX, 3NZ0, 3ZON, 4GFO, 4GIH, 4GII, 4GJ2, 4GJ3, 4GVJ, 4OLI, 4PO6, 4PY1, 4WOV, 5C01, 5C03, 5F20, 5F1Z
Identifiers
Aliases	TYK2, IMD35, JTK1, tyrosine kinase 2, Non-receptor tyrosine-protein kinase
External IDs	OMIM: 176941 MGI: 1929470 HomoloGene: 20712 GeneCards: TYK2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,380,572 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,042,539 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right lobe of thyroid gland; ; spleen; ; right uterine tube; ; right lobe of liver; ; tibial nerve; ; left lobe of thyroid gland; ; upper lobe of left lung; ; canal of the cervix; ; left uterine tube;
	Top expressed in
	spermatocyte; ; blood; ; renal corpuscle; ; spleen; ; lip; ; bone marrow; ; jejunum; ; submandibular gland; ; Paneth cell; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; type 1 angiotensin receptor binding; growth hormone receptor binding; kinase activity; protein binding; protein tyrosine kinase activity; ATP binding; non-membrane spanning protein tyrosine kinase activity;
Cellular component	cytoplasm; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane; extracellular exosome; cytoskeleton; nucleus;
Biological process	cell differentiation; intracellular signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; regulation of type I interferon-mediated signaling pathway; regulation of cell population proliferation; type I interferon signaling pathway; peptidyl-tyrosine autophosphorylation; innate immune response; cell migration; interleukin-12-mediated signaling pathway; peptidyl-tyrosine phosphorylation; cytokine-mediated signaling pathway; interleukin-23-mediated signaling pathway; interleukin-27-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7297
	54721
	ENSG00000105397
	ENSMUSG00000032175
	P29597
	Q9R117
	NM_003331
	NM_001205312; NM_018793
	NP_003322
	NP_001192241; NP_061263
	Wikidata
View/Edit Human	View/Edit Mouse

Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene.

TYK2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling.

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