Janus kinase 1

JAK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8, 5IXD, 5IXI
Identifiers
Aliases	JAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE
External IDs	OMIM: 147795 MGI: 96628 HomoloGene: 1678 GeneCards: JAK1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	65,067,754 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	101,265,282 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; lymph node; ; superficial temporal artery; ; parietal pleura; ; sperm; ; palpebral conjunctiva; ; right lung; ; subcutaneous adipose tissue; ; lower lobe of lung; ; blood;
	Top expressed in
	lymph node; ; triceps brachii muscle; ; ankle; ; sternocleidomastoid muscle; ; blood; ; temporal muscle; ; spleen; ; thymus; ; digastric muscle; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; CCR5 chemokine receptor binding; growth hormone receptor binding; metal ion binding; kinase activity; protein binding; protein tyrosine kinase activity; protein phosphatase binding; signaling receptor binding; ATP binding; ubiquitin protein ligase binding; non-membrane spanning protein tyrosine kinase activity;
Cellular component	cytoplasm; cytosol; membrane; focal adhesion; extrinsic component of cytoplasmic side of plasma membrane; cytoskeleton; endomembrane system; nucleus; endosome;
Biological process	cell differentiation; intracellular signal transduction; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; interferon-gamma-mediated signaling pathway; response to antibiotic; MAPK cascade; positive regulation of sprouting angiogenesis; protein phosphorylation; regulation of type I interferon-mediated signaling pathway; regulation of interferon-gamma-mediated signaling pathway; regulation of cell population proliferation; type I interferon signaling pathway; interleukin-2-mediated signaling pathway; peptidyl-tyrosine autophosphorylation; protein autophosphorylation; cell migration; innate immune response; interleukin-12-mediated signaling pathway; interleukin-7-mediated signaling pathway; interleukin-15-mediated signaling pathway; interleukin-9-mediated signaling pathway; regulation of molecular function; peptidyl-tyrosine phosphorylation; cytokine-mediated signaling pathway; interleukin-21-mediated signaling pathway; interleukin-6-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3716
	16451
	ENSG00000162434
	ENSMUSG00000028530
	P23458
	P52332
NM_002227; NM_001320923; NM_001321852; NM_001321853; NM_001321854;
	NM_001321855; NM_001321856; NM_001321857
	NM_146145; NM_013567
NP_001307852; NP_001308781; NP_001308782; NP_001308783; NP_001308784;
	NP_001308785; NP_001308786; NP_002218
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.