Thyrotropin receptor

TSHR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XWT, 3G04
Identifiers
Aliases	TSHR, CHNG1, LGR3, hTSHR-I, thyroid stimulating hormone receptor, Thyrotropin receptor, thyrotropin (TSH) receptor
External IDs	OMIM: 603372 MGI: 98849 HomoloGene: 315 GeneCards: TSHR
Gene location (Human)
Chr.	Chromosome 14 (human)
End	81,146,306 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	91,516,582 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; thymus; ; bone marrow cells; ; lymph node; ; right lobe of liver; ; spleen; ; ganglionic eminence; ; thymus; ; sural nerve;
	Top expressed in
	retinal pigment epithelium; ; white adipose tissue; ; subcutaneous adipose tissue; ; spermatocyte; ; brown adipose tissue; ; spermatid; ; median eminence; ; uterus; ; lobe of thyroid gland; ; arcuate nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; protein binding; G protein-coupled receptor activity; protein-hormone receptor activity; signal transducer activity; thyroid-stimulating hormone receptor activity; protein-containing complex binding; signaling receptor activity;
Cellular component	integral component of membrane; receptor complex; integral component of plasma membrane; membrane; cell surface; plasma membrane; basolateral plasma membrane; intracellular anatomical structure;
Biological process	cell-cell signaling; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of cell population proliferation; activation of adenylate cyclase activity; hormone-mediated signaling pathway; signal transduction; nervous system development; cell surface receptor signaling pathway; positive regulation of adenylate cyclase activity; cellular response to glycoprotein; cellular response to thyrotropin-releasing hormone; thyroid-stimulating hormone signaling pathway; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7253
	22095
	ENSG00000165409
	ENSMUSG00000020963
	P16473
	P47750
	NM_000369; NM_001018036; NM_001142626
	NM_001113404; NM_011648
	NP_000360; NP_001018046; NP_001136098
	NP_001106875; NP_035778
	Wikidata
View/Edit Human	View/Edit Mouse

The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins and is coupled to the G_s protein.

It is primarily found on the surface of the thyroid epithelial cells, but also found on adipose tissue and fibroblasts. The latter explains the reason of the myxedema finding during Graves disease. In addition, it has also been found to be expressed in the anterior pituitary gland, hypothalamus and kidneys. Its presence in the anterior pituitary gland may be involved in mediating the paracrine signaling feedback inhibition of thyrotropin along the hypothalamus-pituitary-thyroid axis.

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