Thyrotropin-releasing hormone receptor

TRHR
Identifiers
Aliases	TRHR, TRH-R, thyrotropin releasing hormone receptor, CHNG7
External IDs	OMIM: 188545 MGI: 98824 HomoloGene: 20707 GeneCards: TRHR
Gene location (Human)
Chr.	Chromosome 8 (human)
End	109,121,565 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	44,099,308 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; pituitary gland; ; anterior pituitary; ; ventricle; ; atrium; ; left ventricle; ; hippocampal formation; ; thyroid gland; ; left lobe of thyroid gland; ; hippocampus proper;
	Top expressed in
	facial motor nucleus; ; anterior horn of spinal cord; ; motor neuron; ; ventral tegmental area; ; urethra; ; nucleus accumbens; ; subiculum; ; substantia nigra; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; thyrotropin-releasing hormone receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7201
	22045
	ENSG00000174417
	ENSMUSG00000038760
	P34981
	P21761
	NM_003301
	NM_013696
	NP_003292
	NP_038724
	Wikidata
View/Edit Human	View/Edit Mouse

Thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone.

The TRHR is found on the cell membrane of thyrotropes of the anterior pituitary. When the TRHR is activated it associates with a G_αq/11 protein. The TRHR-G protein complex then activates phospholipase C, which causes the formation of inositol triphosphate (IP3) and diacylglycerol (DAG). This leads to an increase in cytoplasmic calcium ion concentrations which stimulates the exocytosis of thyroid-stimulating hormone (TSH) into the blood.

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