TICAM1

TICAM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M1X, 2M63, 3RC4, 4BSX, 4C0M, 5JEL
Identifiers
Aliases	TICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF, toll like receptor adaptor molecule 1, TIR domain containing adaptor molecule 1
External IDs	OMIM: 607601 MGI: 2147032 HomoloGene: 8605 GeneCards: TICAM1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,831,712 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,583,786 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; gastrocnemius muscle; ; ascending aorta; ; skin of abdomen; ; body of stomach; ; right lobe of liver; ; monocyte; ; right coronary artery; ; popliteal artery; ; duodenum;
	Top expressed in
	jejunum; ; ileum; ; duodenum; ; lacrimal gland; ; epithelium of stomach; ; urethra; ; female urethra; ; yolk sac; ; colon; ; male urethra;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; protein binding; protein kinase binding;
Cellular component	cytosol; ripoptosome; autophagosome; endosome membrane; cytoplasmic vesicle;
Biological process	response to exogenous dsRNA; immune system process; positive regulation of nitric oxide biosynthetic process; positive regulation of natural killer cell activation; macrophage activation involved in immune response; response to lipopolysaccharide; positive regulation of B cell proliferation; positive regulation of NF-kappaB transcription factor activity; defense response to virus; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of B cell activation; positive regulation of protein binding; inflammatory response; I-kappaB kinase/NF-kappaB signaling; positive regulation of protein ubiquitination; regulation of protein homodimerization activity; positive regulation of type I interferon production; MyD88-independent toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; signal transduction; necroptosis; apoptotic signaling pathway; apoptotic process; negative regulation of MyD88-independent toll-like receptor signaling pathway; innate immune response; positive regulation of autophagy; TRIF-dependent toll-like receptor signaling pathway; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	148022
	106759
	ENSG00000127666
	ENSMUSG00000047123
	Q8IUC6
	Q80UF7
	NM_182919; NM_014261; NM_001385678; NM_001385679; NM_001385680
	NM_174989
	NP_891549
	NP_778154
	Wikidata
View/Edit Human	View/Edit Mouse

TIR domain containing adaptor molecule 1 (TICAM1; formerly known as TIR-domain-containing adapter-inducing interferon-β or TRIF) is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter.

Toll-like receptors (TLRs) recognize specific components of microbial invaders and activate an immune response to these pathogens. After these receptors recognize highly conserved pathogenic patterns, a downstream signaling cascade is activated in order to stimulate the release of inflammatory cytokines and chemokines as well as to upregulate the expression of immune cells. All TLRs have a TIR domain that initiates the signaling cascade through TIR adapters. Adapters are platforms that organize downstream signaling cascades leading to a specific cellular response after exposure to a given pathogen.

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