MYD88

MYD88
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JS7, 2Z5V, 3MOP, 4DOM, 4EO7
Identifiers
Aliases	MYD88, MYD88D, myeloid differentiation primary response 88, innate immune signal transduction adaptor, MYD88 innate immune signal transduction adaptor, IMD68
External IDs	OMIM: 602170 MGI: 108005 HomoloGene: 1849 GeneCards: MYD88
Gene location (Human)
Chr.	Chromosome 3 (human)
End	38,143,022 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	119,170,477 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; periodontal fiber; ; palpebral conjunctiva; ; bone marrow; ; spongy bone; ; appendix; ; lower lobe of lung; ; jejunal mucosa; ; spleen;
	Top expressed in
	right lung lobe; ; lip; ; ankle joint; ; uterus; ; esophagus; ; blood; ; duodenum; ; epithelium of stomach; ; spleen; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	death receptor binding; protein binding; TIR domain binding; identical protein binding; protein self-association; Toll-like receptor binding;
Cellular component	cytosol; plasma membrane; endosome membrane; cytoplasm; nucleus;
Biological process	response to interleukin-1; immune system process; negative regulation of apoptotic process; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; cell surface receptor signaling pathway; cellular response to mechanical stimulus; regulation of inflammatory response; positive regulation of interleukin-6 production; positive regulation of I-kappaB kinase/NF-kappaB signaling; toll-like receptor 9 signaling pathway; positive regulation of interleukin-17 production; inflammatory response; 3'-UTR-mediated mRNA stabilization; positive regulation of type I interferon production; positive regulation of interleukin-23 production; signal transduction; defense response to Gram-positive bacterium; positive regulation of NF-kappaB transcription factor activity; apoptotic process; innate immune response; type I interferon signaling pathway; positive regulation of gene expression; positive regulation of interleukin-8 production; defense response to bacterium; interleukin-1-mediated signaling pathway; cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of cytokine production involved in inflammatory response; phagocytosis; Toll signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4615
	17874
	ENSG00000172936
	ENSMUSG00000032508
	Q99836
	P22366
NM_001172566; NM_001172567; NM_001172568; NM_001172569; NM_002468;
	NM_001365876; NM_001365877; NM_001374787; NM_001374788
	NM_010851
NP_001166037; NP_001166038; NP_001166039; NP_001166040; NP_002459;
	NP_001352805; NP_001352806; NP_001361716; NP_001361717
	NP_034981
	Wikidata
View/Edit Human	View/Edit Mouse

Myeloid differentiation primary response 88 (MYD88) is a protein that, in humans, is encoded by the MYD88 gene. originally discovered in the laboratory of Dan A. Liebermann (Lord et al. Oncogene 1990) as a Myeloid differentiation primary response gene.

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