TRIB2

TRIB2
Identifiers
Aliases	TRIB2, C5FW, GS3955, TRB2, tribbles pseudokinase 2
External IDs	OMIM: 609462 MGI: 2145021 HomoloGene: 41445 GeneCards: TRIB2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	12,742,734 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	15,866,923 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; tibial nerve; ; trigeminal ganglion; ; spleen; ; renal medulla; ; left adrenal gland; ; right adrenal gland; ; lymph node; ; spinal ganglia; ; frontal pole;
	Top expressed in
	cumulus cell; ; vas deferens; ; medial ganglionic eminence; ; interventricular septum; ; atrioventricular valve; ; saccule; ; retina; ; endocardial cushion; ; left lung lobe; ; right lung lobe;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein kinase activity; protein kinase inhibitor activity; transcription factor binding; mitogen-activated protein kinase kinase binding; ubiquitin protein ligase binding; ubiquitin-protein transferase regulator activity;
Cellular component	cytoplasm; cytoskeleton; nucleus;
Biological process	regulation of MAP kinase activity; protein phosphorylation; negative regulation of fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	28951
	217410
	ENSG00000071575
	ENSMUSG00000020601
	Q92519
	Q8K4K3
	NM_021643
	NM_144551
	NP_067675
	NP_653134
	Wikidata
View/Edit Human	View/Edit Mouse

Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2 gene. TRIB2 is a pseudokinase member of the (pseudoenzyme) class of signaling/scaffold proteins, possessing little vestigial catalytic output in vitro. It is known to signal to canonical MAPK pathways and to regulate the ubiquitination of substrates with important functions in the immune system. It has also been associated with various diseases, especially in vertebrate leukaemia models. Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target,

and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation High levels of autoantibodies against TRIB2 in Hcrt neurons (in lateral and posterior hypothalamus) seem also closely related to some cases of narcolepsy + cataplexy (N+C)

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