TRIB1

TRIB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5CEM, 5CEK, 5IGO, 5IGQ
Identifiers
Aliases	TRIB1, C8FW, GIG-2, GIG2, SKIP1, TRB-1, TRB1, tribbles pseudokinase 1
External IDs	OMIM: 609461 MGI: 2443397 HomoloGene: 75216 GeneCards: TRIB1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	125,438,403 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	59,528,948 bp
RNA expression pattern
	Top expressed in
	mucosa of urinary bladder; ; visceral pleura; ; gallbladder; ; parotid gland; ; kidney tubule; ; thyroid gland; ; left lobe of thyroid gland; ; lactiferous duct; ; right lobe of thyroid gland; ; bone marrow cells;
	Top expressed in
	retinal pigment epithelium; ; parotid gland; ; lacrimal gland; ; islet of Langerhans; ; left colon; ; lens; ; lip; ; morula; ; left lobe of liver; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; ubiquitin-protein transferase regulator activity; protein kinase inhibitor activity; transcription factor binding; protein binding; mitogen-activated protein kinase kinase binding; ATP binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; nucleus;
Biological process	negative regulation of smooth muscle cell proliferation; negative regulation of protein kinase activity; positive regulation of macrophage differentiation; negative regulation of smooth muscle cell migration; negative regulation of DNA-binding transcription factor activity; negative regulation of neutrophil differentiation; negative regulation of lipopolysaccharide-mediated signaling pathway; protein phosphorylation; JNK cascade; response to lipopolysaccharide; positive regulation of eosinophil differentiation; regulation of MAP kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10221
	211770
	ENSG00000173334
	ENSMUSG00000032501
	Q96RU8
	Q8K4K4
	NM_001282985; NM_025195
	NM_144549
	NP_001269914; NP_079471
	NP_653132
	Wikidata
View/Edit Human	View/Edit Mouse

Tribbles homolog 1 is a protein kinase that in humans is encoded by the TRIB1 gene. Orthologs of this protein pseudokinase (pseudoenzyme) can be found almost ubiquitously throughout the animal kingdom. It exerts its biological functions through binding to signalling proteins of the MAPKK level of the MAPK pathway, therefore eliciting a regulatory role in the function of this pathway which mediates proliferation, apoptosis and differentiation in cells. Tribbles-1 is encoded by the trib1 gene, which in humans can be found on chromosome 8 at position 24.13 on the longest arm (q). Recent crystal structures show that Tribbles 1 has an unusual 3D structure, containing a 'broken' C-helix region, a binding site for ubiquitinated substrates such as C/EBPalpha and a key regulatory C-tail region. Like TRIB2 and TRIB3, TRIB1 has recently been considered as a potential allosteric drug target.

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