TRAIL

TNFSF10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D0G, 1D2Q, 1D4V, 1DG6, 1DU3, 4N90
Identifiers
Aliases	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A, tumor necrosis factor superfamily member 10, TNF superfamily member 10
External IDs	OMIM: 603598 MGI: 107414 HomoloGene: 2824 GeneCards: TNFSF10
Gene location (Human)
Chr.	Chromosome 3 (human)
End	172,523,475 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	27,396,576 bp
RNA expression pattern
	Top expressed in
	urethra; ; monocyte; ; bronchial epithelial cell; ; jejunal mucosa; ; palpebral conjunctiva; ; renal medulla; ; rectum; ; lower lobe of lung; ; human penis; ; pericardium;
	Top expressed in
	conjunctival fornix; ; right lung lobe; ; submandibular gland; ; proximal tubule; ; duodenum; ; jejunum; ; ileum; ; temporal muscle; ; left lung lobe; ; Paneth cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; metal ion binding; protein binding; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; signaling receptor binding; zinc ion binding; identical protein binding; TRAIL binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; extracellular region; extracellular exosome; extracellular space; plasma membrane;
Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cell-cell signaling; cell surface receptor signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of release of cytochrome c from mitochondria; positive regulation of extrinsic apoptotic signaling pathway; regulation of extrinsic apoptotic signaling pathway via death domain receptors; activation of cysteine-type endopeptidase activity involved in apoptotic process; signal transduction; apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of apoptotic process; male gonad development; response to insulin; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	8743
	22035
	ENSG00000121858
	ENSMUSG00000039304
	P50591
	P50592
	NM_001190942; NM_001190943; NM_003810
	NM_009425
	NP_001177871; NP_001177872; NP_003801
	NP_033451
	Wikidata
View/Edit Human	View/Edit Mouse

In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces the process of cell death called apoptosis.

TRAIL is a cytokine that is produced and secreted by most normal tissue cells. It causes apoptosis primarily in tumor cells, by binding to certain death receptors. TRAIL and its receptors have been used as the targets of several anti-cancer therapeutics since the mid-1990s, such as Mapatumumab. However, as of 2013, these have not shown significant survival benefit. TRAIL has also been implicated as a pathogenic or protective factor in various pulmonary diseases, particularly pulmonary arterial hypertension.

TRAIL has also been designated CD253 (cluster of differentiation 253) and TNFSF10 (tumor necrosis factor (ligand) superfamily, member 10).

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