Tankyrase

Tankyrase, also known as tankyrase 1, is an enzyme that in humans is encoded by the TNKS gene. It inhibits the binding of TERF1 to telomeric DNA. Tankyrase attracts substantial interest in cancer research through its interaction with AXIN1 and AXIN2, which are negative regulators of pro-oncogenic β-catenin signaling. Importantly, activity in the β-catenin destruction complex can be increased by tankyrase inhibitors and thus such inhibitors are a potential therapeutic option to reduce the growth of β-catenin-dependent cancers.

TNKS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTNKS, ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5, tankyrase
External IDsOMIM: 603303 MGI: 1341087 HomoloGene: 18405 GeneCards: TNKS
Orthologs
SpeciesHumanMouse
Entrez

8658

21951

Ensembl

ENSG00000173273
ENSG00000285372

ENSMUSG00000031529

UniProt

O95271

Q6PFX9

RefSeq (mRNA)

NM_003747

NM_175091

RefSeq (protein)

NP_003738

NP_780300

Location (UCSC)Chr 8: 9.56 – 9.78 MbChr 8: 35.29 – 35.43 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse
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