Tankyrase

TNKS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RF5, 3UDD, 3UH2, 3UH4, 4DVI, 4I9I, 4K4E, 4K4F, 4KRS, 4LI6, 4LI7, 4LI8, 4MSG, 4MSK, 4MT9, 4N3R, 4N4V, 4OA7, 4TOR, 4TOS, 4U6A, 4UUH, 4UW1, 4W5S, 4W6E, 5ECE, 5EBT, 5ETY
Identifiers
Aliases	TNKS, ARTD5, PARP-5a, PARP5A, PARPL, TIN1, TINF1, TNKS1, pART5, tankyrase
External IDs	OMIM: 603303 MGI: 1341087 HomoloGene: 18405 GeneCards: TNKS
Gene location (Human)
Chr.	Chromosome 8 (human)
End	9,782,346 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	35,432,844 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; internal globus pallidus; ; Brodmann area 23; ; corpus callosum; ; pons; ; superior vestibular nucleus; ; inferior ganglion of vagus nerve; ; corpus epididymis; ; tibia; ; subthalamic nucleus;
	Top expressed in
	hand; ; superior cervical ganglion; ; otolith organ; ; utricle; ; habenula; ; secondary oocyte; ; atrioventricular valve; ; pontine nuclei; ; ventral tegmental area; ; seminiferous tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; histone binding; zinc ion binding; metal ion binding; protein binding; NAD+ ADP-ribosyltransferase activity; protein ADP-ribosylase activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; spindle pole; pericentriolar material; membrane; Golgi membrane; nuclear pore; chromosome; telomere; chromosome, centromeric region; cytoskeleton; nucleus; nucleoplasm; nuclear body; nuclear membrane; mitotic spindle pole; microtubule organizing center;
Biological process	protein auto-ADP-ribosylation; mRNA transport; protein ADP-ribosylation; positive regulation of telomere capping; mitotic spindle organization; protein polyubiquitination; protein localization to chromosome, telomeric region; cell division; spindle assembly; peptidyl-serine phosphorylation; positive regulation of telomerase activity; negative regulation of telomere maintenance via telomere lengthening; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein transport; cell cycle; peptidyl-threonine phosphorylation; regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; protein poly-ADP-ribosylation; negative regulation of telomeric DNA binding; positive regulation of canonical Wnt signaling pathway; positive regulation of telomere maintenance via telomerase; Wnt signaling pathway; cellular response to nutrient;
	Sources:Amigo / QuickGO
Orthologs
	8658
	21951
	ENSG00000173273; ENSG00000285372
	ENSMUSG00000031529
	O95271
	Q6PFX9
	NM_003747
	NM_175091
	NP_003738
	NP_780300
	Wikidata
View/Edit Human	View/Edit Mouse

Tankyrase, also known as tankyrase 1, is an enzyme that in humans is encoded by the TNKS gene. It inhibits the binding of TERF1 to telomeric DNA. Tankyrase attracts substantial interest in cancer research through its interaction with AXIN1 and AXIN2, which are negative regulators of pro-oncogenic β-catenin signaling. Importantly, activity in the β-catenin destruction complex can be increased by tankyrase inhibitors and thus such inhibitors are a potential therapeutic option to reduce the growth of β-catenin-dependent cancers.

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