AXIN2

AXIN2
Identifiers
Aliases	AXIN2, AXIL, ODCRCS, axin 2
External IDs	OMIM: 604025 MGI: 1270862 HomoloGene: 3420 GeneCards: AXIN2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	65,561,648 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	108,841,609 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; thymus; ; germinal epithelium; ; right lung; ; right uterine tube; ; upper lobe of lung; ; upper lobe of left lung; ; canal of the cervix; ; left uterine tube; ; endometrium;
	Top expressed in
	primitive streak; ; hair follicle; ; iris; ; Paneth cell; ; lamina propria of urinary bladder; ; maxillary prominence; ; condyloid process; ; secondary oocyte; ; palate; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	I-SMAD binding; GTPase activator activity; protein binding; enzyme binding; ubiquitin protein ligase binding; beta-catenin binding;
Cellular component	cytoplasm; cytosol; centrosome; plasma membrane; nucleus; beta-catenin destruction complex;
Biological process	regulation of mismatch repair; intramembranous ossification; somitogenesis; bone mineralization; positive regulation of protein phosphorylation; positive regulation of cell death; regulation of centromeric sister chromatid cohesion; positive regulation of canonical Wnt signaling pathway; positive regulation of epithelial to mesenchymal transition; negative regulation of osteoblast differentiation; odontogenesis; multicellular organism development; mRNA stabilization; maintenance of DNA repeat elements; regulation of Wnt signaling pathway; chondrocyte differentiation involved in endochondral bone morphogenesis; regulation of chondrocyte development; secondary heart field specification; cell population proliferation; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; positive regulation of GTPase activity; beta-catenin-TCF complex assembly; Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8313
	12006
	ENSG00000168646
	ENSMUSG00000000142
	Q9Y2T1
	O88566
	NM_004655; NM_001363813
	NM_015732
	NP_004646; NP_001350742
	NP_056547
	Wikidata
View/Edit Human	View/Edit Mouse

Axin-2, also known as axin-like protein (Axil), axis inhibition protein 2 (AXIN2), or conductin, is a protein that in humans is encoded by the AXIN2 gene.

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