Tumor necrosis factor receptor 2

TNFRSF1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CA9, 3ALQ
Identifiers
Aliases	TNFRSF1B, CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR, tumor necrosis factor receptor superfamily member 1B, TNF receptor superfamily member 1B
External IDs	OMIM: 191191 MGI: 1314883 HomoloGene: 829 GeneCards: TNFRSF1B
Gene location (Human)
Chr.	Chromosome 1 (human)
End	12,209,228 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	144,973,440 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spleen; ; appendix; ; right lung; ; lymph node; ; subcutaneous adipose tissue; ; periodontal fiber; ; upper lobe of left lung; ; pericardium;
	Top expressed in
	aortic valve; ; blood; ; spleen; ; ascending aorta; ; internal carotid artery; ; pyloric antrum; ; left lobe of liver; ; thymus; ; external carotid artery; ; gastric mucosa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase binding; tumor necrosis factor-activated receptor activity; tumor necrosis factor binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; varicosity; extracellular region; axon; neuronal cell body; perinuclear region of cytoplasm; membrane raft; nucleus; specific granule membrane; tumor necrosis factor receptor superfamily complex;
Biological process	extrinsic apoptotic signaling pathway; RNA destabilization; cellular response to growth factor stimulus; positive regulation of membrane protein ectodomain proteolysis; human ageing; multicellular organism development; cell surface receptor signaling pathway; response to lipopolysaccharide; regulation of cell population proliferation; immune response; intrinsic apoptotic signaling pathway in response to DNA damage; apoptotic signaling pathway; inflammatory response; cellular response to lipopolysaccharide; negative regulation of inflammatory response; apoptotic process; tumor necrosis factor-mediated signaling pathway; neutrophil degranulation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cytokine-mediated signaling pathway; aortic valve development; pulmonary valve development; negative regulation of extracellular matrix constituent secretion; negative regulation of cardiac muscle hypertrophy; positive regulation of apoptotic process involved in morphogenesis; regulation of T cell cytokine production; regulation of myelination; regulation of T cell proliferation; regulation of neuroinflammatory response; cellular response to tumor necrosis factor; positive regulation of myelination; positive regulation of oligodendrocyte differentiation; negative regulation of cell death; negative regulation of neuroinflammatory response; glial cell-neuron signaling; negative regulation of neuron death; regulation of RNA biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	7133
	21938
	ENSG00000028137
	ENSMUSG00000028599
	P20333
	P25119
	NM_001066
	NM_011610
	NP_001057
	NP_035740
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα). Like its counterpart, tumor necrosis factor receptor 1 (TNFR1), the extracellular region of TNFR2 consists of four cysteine-rich domains which allow for binding to TNFα. TNFR1 and TNFR2 possess different functions when bound to TNFα due to differences in their intracellular structures, such as TNFR2 lacking a death domain (DD).

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