Tumor necrosis factor receptor 1

TNFRSF1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EXT, 1FT4, 1ICH, 1NCF, 1TNR
Identifiers
Aliases	TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60, tumor necrosis factor receptor superfamily member 1A, TNF receptor superfamily member 1A
External IDs	OMIM: 191190 MGI: 1314884 HomoloGene: 828 GeneCards: TNFRSF1A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,342,114 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	125,339,447 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; left uterine tube; ; right coronary artery; ; upper lobe of left lung; ; pericardium; ; blood; ; smooth muscle tissue; ; left coronary artery; ; right lobe of thyroid gland; ; right adrenal gland;
	Top expressed in
	saccule; ; lip; ; otic placode; ; esophagus; ; calvaria; ; ankle; ; duodenum; ; left lung; ; jejunum; ; adrenal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; tumor necrosis factor-activated receptor activity; tumor necrosis factor binding; identical protein binding;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane; receptor complex; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; mitochondrion; membrane raft; extracellular space; tumor necrosis factor receptor superfamily complex;
Biological process	regulation of apoptotic process; prostaglandin metabolic process; defense response; positive regulation of ceramide biosynthetic process; positive regulation of inflammatory response; regulation of tumor necrosis factor-mediated signaling pathway; tumor necrosis factor-mediated signaling pathway; response to lipopolysaccharide; cellular response to mechanical stimulus; death-inducing signaling complex assembly; regulation of cell population proliferation; defense response to bacterium; immune response; intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of I-kappaB kinase/NF-kappaB signaling; viral process; I-kappaB kinase/NF-kappaB signaling; negative regulation of inflammatory response; regulation of establishment of endothelial barrier; extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of transcription by RNA polymerase II; signal transduction; apoptotic process; inflammatory response; cell surface receptor signaling pathway; positive regulation of tyrosine phosphorylation of STAT protein; protein localization to plasma membrane; cytokine-mediated signaling pathway; aortic valve development; pulmonary valve development; negative regulation of extracellular matrix constituent secretion; negative regulation of cardiac muscle hypertrophy; positive regulation of apoptotic process involved in morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7132
	21937
	ENSG00000067182
	ENSMUSG00000030341
	P19438
	P25118
	NM_001065; NM_001346091; NM_001346092
	NM_011609
	NP_001056; NP_001333020; NP_001333021
	NP_035739
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNFα).

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