TGF alpha

TGFA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GK5, 1MOX, 1YUF, 1YUG, 2TGF, 3E50, 3TGF, 4TGF
Identifiers
Aliases	TGFA, TFGA, transforming growth factor alpha, Transforming growth factor - α
External IDs	OMIM: 190170 MGI: 98724 HomoloGene: 2431 GeneCards: TGFA
Gene location (Human)
Chr.	Chromosome 2 (human)
End	70,554,193 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	86,252,701 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; islet of Langerhans; ; amniotic fluid; ; corpus callosum; ; periodontal fiber; ; gallbladder; ; gums; ; cavity of mouth; ; inferior olivary nucleus; ; secondary oocyte;
	Top expressed in
	olfactory tubercle; ; lip; ; nucleus accumbens; ; belly cord; ; globus pallidus; ; suprachiasmatic nucleus; ; pyloric antrum; ; epithelium of stomach; ; Jacobson's organ; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	epidermal growth factor receptor binding; protein binding; growth factor activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; basolateral plasma membrane; perinuclear region of cytoplasm; ER to Golgi transport vesicle membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; cytoplasmic vesicle; Golgi membrane; extracellular space; clathrin-coated vesicle membrane;
Biological process	positive regulation of epidermal growth factor-activated receptor activity; positive regulation of epithelial cell proliferation; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII vesicle coating; cell population proliferation; positive regulation of mitotic nuclear division; positive regulation of cell division; regulation of transcription by RNA polymerase II; epidermal growth factor receptor signaling pathway; positive regulation of cell population proliferation; MAPK cascade; signal transduction; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; membrane organization; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7039
	21802
	ENSG00000163235
	ENSMUSG00000029999
	P01135
	P48030
	NM_001099691; NM_001308158; NM_001308159; NM_003236
	NM_031199
	NP_001093161; NP_001295087; NP_001295088; NP_003227
	NP_112476; NP_001390047
	Wikidata
View/Edit Human	View/Edit Mouse

Transforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene. As a member of the epidermal growth factor (EGF) family, TGF-α is a mitogenic polypeptide. The protein becomes activated when binding to receptors capable of protein kinase activity for cellular signaling.

TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate.

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