Epidermal growth factor

EGF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IVO, 1JL9, 1NQL, 1P9J, 2KV4, 3NJP
Identifiers
Aliases	EGF, HOMG4, URG, epidermal growth factor, epithelial growth factor
External IDs	OMIM: 131530 MGI: 95290 HomoloGene: 1483 GeneCards: EGF
Gene location (Human)
Chr.	Chromosome 4 (human)
End	110,013,766 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	129,548,965 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; body of pancreas; ; kidney; ; kidney tubule; ; gastrocnemius muscle; ; biceps brachii; ; deltoid muscle; ; vastus lateralis muscle; ; secondary oocyte; ; metanephric glomerulus;
	Top expressed in
	submandibular gland; ; kidney; ; parotid gland; ; prostate; ; extensor digitorum longus muscle; ; plantaris muscle; ; vastus lateralis muscle; ; lacrimal gland; ; triceps brachii muscle; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; transmembrane receptor protein tyrosine kinase activator activity; epidermal growth factor receptor binding; Wnt-protein binding; protein binding; growth factor activity; Wnt-activated receptor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	integral component of membrane; membrane; receptor complex; extracellular region; lysosomal membrane; extracellular exosome; platelet alpha granule lumen; extracellular space; clathrin-coated vesicle membrane; plasma membrane;
Biological process	negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of MAP kinase activity; epidermal growth factor receptor signaling pathway; regulation of protein localization to cell surface; ERK1 and ERK2 cascade; platelet degranulation; regulation of calcium ion import; mammary gland alveolus development; MAPK cascade; DNA replication; positive regulation of transcription, DNA-templated; negative regulation of secretion; positive regulation of hyaluronan biosynthetic process; positive regulation of peptidyl-threonine phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; angiogenesis; Wnt signaling pathway involved in dorsal/ventral axis specification; positive regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cerebellar granule cell precursor proliferation; canonical Wnt signaling pathway; negative regulation of cholesterol efflux; peptidyl-tyrosine phosphorylation; positive regulation of DNA binding; positive regulation of phosphorylation; positive regulation of mitotic nuclear division; branching morphogenesis of an epithelial tube; signal transduction; regulation of peptidyl-tyrosine phosphorylation; ERBB2 signaling pathway; phosphatidylinositol phosphate biosynthetic process; positive regulation of protein tyrosine kinase activity; activation of transmembrane receptor protein tyrosine kinase activity; regulation of cell motility; positive regulation of receptor internalization; positive regulation of epidermal growth factor-activated receptor activity; membrane organization; negative regulation of ERBB signaling pathway; embryonic retina morphogenesis in camera-type eye; positive regulation of gene expression; positive regulation of cell migration; positive regulation of protein kinase B signaling; negative regulation of Notch signaling pathway; regulation of receptor signaling pathway via JAK-STAT; positive regulation of canonical Wnt signaling pathway; positive regulation of protein localization to early endosome;
	Sources:Amigo / QuickGO
Orthologs
	1950
	13645
	ENSG00000138798
	ENSMUSG00000028017
	P01133
	P01132
	NM_001178130; NM_001178131; NM_001963; NM_001357021
	NM_010113; NM_001310737; NM_001329594
	NP_001171601; NP_001171602; NP_001954; NP_001343950
	NP_001297666; NP_001316523; NP_034243
	Wikidata
View/Edit Human	View/Edit Mouse

Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has 53 amino acid residues and three intramolecular disulfide bonds.

EGF was originally described as a secreted peptide found in the submaxillary glands of mice and in human urine. EGF has since been found in many human tissues, including platelets, submandibular gland (submaxillary gland), and parotid gland. Initially, human EGF was known as urogastrone.

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