Transferrin receptor 2

TFR2
Identifiers
Aliases	TFR2, HFE3, TFRC2, transferrin receptor 2
External IDs	OMIM: 604720 MGI: 1354956 HomoloGene: 2428 GeneCards: TFR2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,642,779 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,585,743 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; vena cava; ; spongy bone; ; nipple; ; pylorus; ; pericardium; ; superior surface of tongue; ; sperm; ; saphenous vein; ; bone marrow;
	Top expressed in
	left lobe of liver; ; sexually immature organism; ; motor neuron; ; barrel cortex; ; substantia nigra; ; bone marrow; ; suprachiasmatic nucleus; ; condyle; ; yolk sac; ; Region I of hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferrin receptor activity; co-receptor binding; protein binding;
Cellular component	cytoplasm; integral component of membrane; integral component of plasma membrane; membrane; cytoplasmic vesicle; HFE-transferrin receptor complex; external side of plasma membrane; plasma membrane;
Biological process	positive regulation of endocytosis; receptor-mediated endocytosis; iron ion transport; positive regulation of peptide hormone secretion; cellular response to iron ion; response to iron ion; positive regulation of transcription by RNA polymerase II; cellular iron ion homeostasis; positive regulation of protein maturation; iron ion homeostasis; acute-phase response; transferrin transport; endocytic iron import into cell;
	Sources:Amigo / QuickGO
Orthologs
	7036
	50765
	ENSG00000106327
	ENSMUSG00000029716
	Q9UP52
	Q9JKX3
	NM_001206855; NM_003227
	NM_001289507; NM_001289509; NM_001289511; NM_015799; NM_001359206
	NP_001193784; NP_003218
	NP_001276436; NP_001276438; NP_001276440; NP_056614; NP_001346135
	Wikidata
View/Edit Human	View/Edit Mouse

Transferrin receptor 2 (TfR2) is a protein that in humans is encoded by the TFR2 gene. This protein is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.

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