Transferrin receptor 1

TFRC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CX8, 1DE4, 1SUV, 2NSU, 3KAS, 3S9L, 3S9M, 3S9N
Identifiers
Aliases	TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90, IMD46, transferrin receptor
External IDs	OMIM: 190010 MGI: 98822 HomoloGene: 2429 GeneCards: TFRC
Gene location (Human)
Chr.	Chromosome 3 (human)
End	196,082,096 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	32,451,612 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; spongy bone; ; tibia; ; germinal epithelium; ; visceral pleura; ; hair follicle; ; parietal pleura; ; periodontal fiber; ; bone marrow; ; lower lobe of lung;
	Top expressed in
	body of femur; ; habenula; ; temporal muscle; ; vastus lateralis muscle; ; digastric muscle; ; ankle; ; triceps brachii muscle; ; lacrimal gland; ; sternocleidomastoid muscle; ; medullary collecting duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; virus receptor activity; transferrin receptor activity; identical protein binding; double-stranded RNA binding; RNA binding; protein binding;
Cellular component	extracellular vesicle; integral component of membrane; recycling endosome; HFE-transferrin receptor complex; endosome; blood microparticle; membrane; melanosome; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; basolateral plasma membrane; perinuclear region of cytoplasm; clathrin-coated pit; extracellular exosome; external side of plasma membrane; extracellular space; clathrin-coated vesicle membrane; cytoplasmic vesicle; endosome membrane; early endosome;
Biological process	endocytosis; osteoclast differentiation; positive regulation of bone resorption; receptor-mediated endocytosis; regulation of cell population proliferation; regulation of cell growth; viral entry into host cell; viral process; cellular iron ion homeostasis; positive regulation of isotype switching; receptor internalization; transferrin transport; positive regulation of B cell proliferation; positive regulation of T cell proliferation; membrane organization; cellular response to leukemia inhibitory factor; iron ion transport;
	Sources:Amigo / QuickGO
Orthologs
	7037
	22042
	ENSG00000072274
	ENSMUSG00000022797
	P02786
	Q62351
	NM_001313965; NM_001313966; NM_001128148; NM_003234
	NM_011638; NM_001357298
	NP_001121620; NP_001300894; NP_001300895; NP_003225
	NP_035768; NP_001344227
	Wikidata
View/Edit Human	View/Edit Mouse

Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. TfR1 is required for iron import from transferrin into cells by endocytosis.

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