TBX3

TBX3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H6F
Identifiers
Aliases	TBX3, TBX3-ISO, UMS, XHL, T-box 3, T-box transcription factor 3
External IDs	OMIM: 601621 MGI: 98495 HomoloGene: 4371 GeneCards: TBX3
Gene location (Human)
Chr.	Chromosome 12 (human)
End	114,684,175 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	119,822,789 bp
RNA expression pattern
	Top expressed in
	urethra; ; stromal cell of endometrium; ; seminal vesicula; ; prostate; ; right lobe of thyroid gland; ; right lung; ; left lobe of thyroid gland; ; placenta; ; jejunal mucosa; ; corpus epididymis;
	Top expressed in
	medullary collecting duct; ; adrenal gland; ; seminal vesicula; ; coelomic epithelium; ; jejunum; ; duodenum; ; vas deferens; ; adrenal medulla; ; maxillary prominence; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	forelimb morphogenesis; cellular senescence; branching involved in mammary gland duct morphogenesis; positive regulation of stem cell proliferation; atrioventricular bundle cell differentiation; negative regulation of epithelial cell differentiation; female genitalia development; transcription, DNA-templated; male genitalia development; multicellular organism development; anterior/posterior axis specification, embryo; outflow tract morphogenesis; skeletal system development; ventricular septum morphogenesis; embryonic forelimb morphogenesis; cardiac muscle cell fate commitment; regulation of transcription by RNA polymerase II; heart morphogenesis; regulation of cell population proliferation; heart looping; negative regulation of myoblast differentiation; specification of animal organ position; stem cell population maintenance; luteinizing hormone secretion; follicle-stimulating hormone secretion; blood vessel development; positive regulation of cell population proliferation; positive regulation of transcription, DNA-templated; roof of mouth development; mammary placode formation; in utero embryonic development; mesoderm morphogenesis; regulation of transcription, DNA-templated; limb morphogenesis; sinoatrial node cell development; positive regulation of cell cycle; cardiac muscle cell differentiation; limbic system development; embryonic hindlimb morphogenesis; animal organ morphogenesis; embryonic heart tube development; embryonic digit morphogenesis; mammary gland development; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	6926
	21386
	ENSG00000135111
	ENSMUSG00000018604
	O15119
	P70324
	NM_016569; NM_005996
	NM_011535; NM_198052
	NP_005987; NP_057653
	NP_035665; NP_932169
	Wikidata
View/Edit Human	View/Edit Mouse

T-box transcription factor TBX3 is a protein that in humans is encoded by the TBX3 gene.

T-box 3 (TBX3) is a member of the T-box gene family of transcription factors which all share a highly conserved DNA binding domain known as the T-box. The T-box gene family consists of 17 members in mouse and humans that are grouped into five subfamilies, namely Brachyury (T), T-brain (Tbr1), TBX1, TBX2, and TBX6. Tbx3 is a member of the Tbx2 subfamily which includes Tbx2, Tbx4 and Tbx5. The human TBX3 gene maps to chromosome 12 at position 12q23-24.1 and consists of 7 exons which encodes a 723 amino acid protein (ENSEMBL assembly release GRCh38.p12).

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.