TBX2

TBX2
Identifiers
Aliases	TBX2, T-box 2, VETD, T-box transcription factor 2
External IDs	OMIM: 600747 MGI: 98494 HomoloGene: 38123 GeneCards: TBX2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	61,409,466 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	85,732,774 bp
RNA expression pattern
	Top expressed in
	right lung; ; right coronary artery; ; upper lobe of left lung; ; right uterine tube; ; left coronary artery; ; seminal vesicula; ; periodontal fiber; ; caput epididymis; ; lower lobe of lung; ; corpus epididymis;
	Top expressed in
	left lung lobe; ; atrioventricular canal; ; maxillary prominence; ; right lung; ; medullary collecting duct; ; molar; ; external carotid artery; ; third ventricle; ; human penis; ; infundibular recess;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus;
Biological process	Notch signaling pathway; roof of mouth development; atrioventricular canal development; pharynx development; regulation of transcription, DNA-templated; regulation of heart contraction; cardiac muscle tissue development; negative regulation of heart looping; mammary placode formation; embryonic digit morphogenesis; heart morphogenesis; outflow tract morphogenesis; negative regulation of transcription by RNA polymerase II; aorta morphogenesis; transcription, DNA-templated; embryonic heart tube development; outflow tract septum morphogenesis; endocardial cushion morphogenesis; multicellular organism development; heart looping; muscle cell fate determination; cellular senescence; developmental growth involved in morphogenesis; positive regulation of cardiac muscle cell proliferation; embryonic camera-type eye morphogenesis; positive regulation of cell population proliferation; negative regulation of cardiac chamber formation; negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	6909
	21385
	ENSG00000121068
	ENSMUSG00000000093
	Q13207
	Q60707
	NM_005994
	NM_009324
	NP_005985
	NP_033350
	Wikidata
View/Edit Human	View/Edit Mouse

T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Tbx2 and Tbx3 are the only T-box transcription factors that act as transcriptional repressors rather than transcriptional activators, and are closely related in terms of development and tumorigenesis. This gene plays a significant role in embryonic and fetal development through control of gene expression, and also has implications in various cancers. Tbx2 is associated with numerous signaling pathways, BMP, TGFβ, Wnt, and FGF, which allow for patterning and proliferation during organogenesis in fetal development.

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