Syndecan
Syndecans are single transmembrane domain proteins that are thought to act as coreceptors, especially for G protein-coupled receptors. More specifically, these core proteins carry three to five heparan sulfate and chondroitin sulfate chains, i.e. they are proteoglycans, which allow for interaction with a large variety of ligands including fibroblast growth factors, vascular endothelial growth factor, transforming growth factor-beta, fibronectin and antithrombin-1. Interactions between fibronectin and some syndecans can be modulated by the extracellular matrix protein tenascin C.
| Syndecan | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Solution structure of the Syndecan-4 whole cytoplasmic domain in the presence of phosphatidylinositol 4,5-bisphosphate. | |||||||||
| Identifiers | |||||||||
| Symbol | Syndecan | ||||||||
| Pfam | PF01034 | ||||||||
| InterPro | IPR001050 | ||||||||
| PROSITE | PDOC00745 | ||||||||
| SCOP2 | 1ejp / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 535 | ||||||||
| OPM protein | 6ith | ||||||||
| Membranome | 18 | ||||||||
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