Tenascin C

TNC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TEN, 2RB8, 2RBL
Identifiers
Aliases	TNC, 150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C, Tenascin C
External IDs	OMIM: 187380 MGI: 101922 HomoloGene: 55636 GeneCards: TNC
Gene location (Human)
Chr.	Chromosome 9 (human)
End	115,118,257 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	63,965,252 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; periodontal fiber; ; tibia; ; pericardium; ; superficial temporal artery; ; stromal cell of endometrium; ; appendix; ; vena cava; ; synovial joint; ; smooth muscle tissue;
	Top expressed in
	body of femur; ; molar; ; calvaria; ; facial skeleton; ; second toe; ; belly cord; ; maxillary nerve; ; third toe; ; ankle joint; ; nasal septum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	syndecan binding; extracellular matrix structural constituent; protein binding;
Cellular component	interstitial matrix; membrane; focal adhesion; extracellular matrix; basement membrane; extracellular space; endoplasmic reticulum lumen; extracellular region; collagen-containing extracellular matrix; perisynaptic extracellular matrix;
Biological process	cellular response to retinoic acid; negative regulation of cell adhesion; bud outgrowth involved in lung branching; mesenchymal-epithelial cell signaling involved in prostate gland development; response to fibroblast growth factor; response to mechanical stimulus; extracellular matrix organization; wound healing; cellular response to vitamin D; odontogenesis of dentin-containing tooth; positive regulation of gene expression; cell adhesion; prostate gland epithelium morphogenesis; cellular response to prostaglandin D stimulus; regulation of cell population proliferation; neuromuscular junction development; response to wounding; peripheral nervous system axon regeneration; osteoblast differentiation; positive regulation of cell population proliferation; response to ethanol; neuron projection development; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	3371
	21923
	ENSG00000041982
	ENSMUSG00000028364
	P24821
	Q80YX1
	NM_002160
	NM_011607; NM_001369211; NM_001369212; NM_001369213; NM_001369214
	NP_002151
	NP_035737; NP_001356140; NP_001356141; NP_001356142; NP_001356143
	Wikidata
View/Edit Human	View/Edit Mouse

Tenascin C (TN-C) is a glycoprotein that in humans is encoded by the TNC gene. It is expressed in the extracellular matrix of various tissues during development, disease or injury, and in restricted neurogenic areas of the central nervous system. Tenascin-C is the founding member of the tenascin protein family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage.

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