Stimulator of interferon genes

STING1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4EF4, 4EF5, 4EMT, 4EMU, 4F5D, 4F5E, 4F5W, 4F5Y, 4F9E, 4F9G, 4KSY, 4LOH, 4LOI, 4QXO, 4QXP, 4QXQ, 4QXR, 5BQX, 5JEJ
Identifiers
Aliases	STING1, ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING, Stimulator of interferon genes, transmembrane protein 173, STING-beta, TMEM173, stimulator of interferon response cGAMP interactor 1
External IDs	OMIM: 612374 MGI: 1919762 HomoloGene: 18868 GeneCards: STING1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	139,482,935 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	35,873,607 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; gastric mucosa; ; right coronary artery; ; upper lobe of left lung; ; left uterine tube; ; ascending aorta; ; spleen; ; left coronary artery; ; monocyte; ; appendix;
	Top expressed in
	interventricular septum; ; spleen; ; blood; ; thymus; ; cervix; ; internal carotid artery; ; external carotid artery; ; bone marrow; ; Paneth cell; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; cyclic-di-GMP binding; protein homodimerization activity; transcription factor binding; protein binding; identical protein binding; protein kinase binding; ubiquitin protein ligase binding; 2',3'-cyclic GMP-AMP binding;
Cellular component	cytoplasm; integral component of membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; peroxisome; mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasmic vesicle membrane; plasma membrane; secretory granule membrane;
Biological process	interferon-beta production; cellular response to interferon-beta; immune system process; regulation of type I interferon production; defense response to virus; cellular response to exogenous dsRNA; activation of innate immune response; positive regulation of protein binding; positive regulation of transcription by RNA polymerase II; positive regulation of defense response to virus by host; apoptotic process; innate immune response; neutrophil degranulation; cellular response to organic cyclic compound; viral process; positive regulation of DNA-binding transcription factor activity; positive regulation of type I interferon production; regulation of gene expression; regulation of cellular metabolic process; regulation of inflammatory response; cytoplasmic pattern recognition receptor signaling pathway in response to virus;
	Sources:Amigo / QuickGO
Orthologs
	340061
	72512
	ENSG00000184584; ENSG00000288243
	ENSMUSG00000024349
	Q86WV6
	Q3TBT3
	NM_001301738; NM_198282; NM_001367258
	NM_001289591; NM_001289592; NM_028261
	NP_001288667; NP_938023; NP_001354187
	NP_001276520; NP_001276521; NP_082537
	Wikidata
View/Edit Human	View/Edit Mouse

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene.

STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection.

STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.

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