STAT6

STAT6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OJ5, 4Y5W, 4Y5U
Identifiers
Aliases	STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6
External IDs	OMIM: 601512 MGI: 103034 HomoloGene: 2373 GeneCards: STAT6
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,132,139 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,496,826 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; spleen; ; gastric mucosa; ; right uterine tube; ; left uterine tube; ; transverse colon; ; monocyte; ; right coronary artery; ; skin of abdomen; ; upper lobe of left lung;
	Top expressed in
	ascending aorta; ; aortic valve; ; thymus; ; spleen; ; lip; ; esophagus; ; subcutaneous adipose tissue; ; blood; ; corneal stroma; ; right lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	identical protein binding; sequence-specific DNA binding; protein phosphatase binding; DNA binding; protein binding; DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; membrane raft; cytoplasm; cytosol; nuclear membrane;
Biological process	regulation of transcription by RNA polymerase II; T-helper 1 cell lineage commitment; regulation of cell population proliferation; response to cytokine; interleukin-4-mediated signaling pathway; regulation of transcription, DNA-templated; cellular response to hydrogen peroxide; mammary gland epithelial cell proliferation; cellular response to reactive nitrogen species; positive regulation of type I interferon production; positive regulation of isotype switching to IgE isotypes; mammary gland morphogenesis; negative regulation of type 2 immune response; negative regulation of transcription by RNA polymerase II; signal transduction; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; cytokine-mediated signaling pathway; positive regulation of cold-induced thermogenesis; defense response; receptor signaling pathway via JAK-STAT; response to peptide hormone; growth hormone receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologs
	6778
	20852
	ENSG00000166888
	ENSMUSG00000002147
	P42226
	P52633
	NM_001178078; NM_001178079; NM_001178080; NM_001178081; NM_003153
	NM_009284
	NP_001171549; NP_001171550; NP_001171551; NP_001171552; NP_003144
	NP_033310
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. Similarly as other STAT family proteins, STAT6 is also activated by growth factors and cytokines. STAT6 is mainly activated by cytokines interleukin-4 and interleukin-13.

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