Tyrosine-protein kinase CSK

CSK
Available structures
PDB	Ortholog search: H3BU69 PDBe H3BU69 RCSB
List of PDB id codes
	1BYG, 1CSK, 3D7T, 3D7U, 3EAC, 3EAZ
Identifiers
Aliases	CSK, Src, c-src tyrosine kinase, CSK/Src, non-receptor tyrosine kinase, C-terminal Src kinase
External IDs	OMIM: 190090, 124095 MGI: 88537 HomoloGene: 55818 GeneCards: CSK
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,803,198 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,560,914 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; blood; ; lymph node; ; appendix; ; thymus; ; bone marrow cells; ; stromal cell of endometrium; ; pancreatic ductal cell; ; right lobe of liver;
	Top expressed in
	thymus; ; spleen; ; lip; ; blood; ; yolk sac; ; esophagus; ; ankle joint; ; ganglionic eminence; ; bone marrow; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein kinase A catalytic subunit binding; non-membrane spanning protein tyrosine kinase activity; metal ion binding; protein C-terminus binding; protein binding; identical protein binding; protein tyrosine kinase activity; protein phosphatase binding; proline-rich region binding; signaling receptor binding; ATP binding; kinase activity;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; membrane raft; extracellular exosome;
Biological process	cell differentiation; adaptive immune response; positive regulation of MAP kinase activity; epidermal growth factor receptor signaling pathway; negative regulation of phagocytosis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of low-density lipoprotein particle clearance; immune system process; negative regulation of interleukin-6 production; T cell costimulation; oligodendrocyte differentiation; negative regulation of Golgi to plasma membrane protein transport; regulation of Fc receptor mediated stimulatory signaling pathway; regulation of cytokine production; protein phosphorylation; brain development; cellular response to peptide hormone stimulus; regulation of cell population proliferation; peptidyl-tyrosine autophosphorylation; negative regulation of ERK1 and ERK2 cascade; protein autophosphorylation; innate immune response; adherens junction organization; T cell receptor signaling pathway; negative regulation of cell population proliferation; negative regulation of bone resorption; negative regulation of kinase activity; central nervous system development; peptidyl-tyrosine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	1445
	12988
	ENSG00000103653
	ENSMUSG00000032312
	P41240
	P41241
	NM_001127190; NM_004383; NM_001354988
	NM_007783; NM_001304761
	NP_001120662; NP_004374; NP_001341917
	NP_001291690; NP_031809
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This enzyme phosphorylates tyrosine residues located in the C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1.

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