FYN

FYN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A0N, 1AOT, 1AOU, 1AVZ, 1AZG, 1EFN, 1FYN, 1G83, 1M27, 1NYF, 1NYG, 1SHF, 1ZBJ, 2DQ7, 3H0F, 3H0H, 3H0I, 3UA6, 3UA7, 4D8D, 4EIK, 2MQI, 2MRJ, 2MRK, 4U17, 4U1P, 4ZNX
Identifiers
Aliases	FYN, SLK, SYN, p59-FYN proto-oncogene, Src family tyrosine kinase
External IDs	OMIM: 137025 MGI: 95602 HomoloGene: 48068 GeneCards: FYN
Gene location (Human)
Chr.	Chromosome 6 (human)
End	111,873,452 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	39,565,381 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; corpus callosum; ; olfactory bulb; ; lymph node; ; optic nerve; ; right lung; ; amygdala; ; monocyte; ; nucleus accumbens; ; thymus;
	Top expressed in
	optic nerve; ; ganglionic eminence; ; olfactory bulb; ; barrel cortex; ; secondary oocyte; ; blood; ; calvaria; ; sciatic nerve; ; medial ganglionic eminence; ; ventromedial nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	CD4 receptor binding; transmembrane transporter binding; protein-containing complex binding; protein binding; CD8 receptor binding; kinase activity; tubulin binding; signaling receptor binding; ATP binding; protein kinase activity; metal ion binding; peptide hormone receptor binding; T cell receptor binding; transferase activity; ephrin receptor binding; nucleotide binding; growth factor receptor binding; phosphatidylinositol 3-kinase binding; G protein-coupled receptor binding; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein tyrosine kinase activity; enzyme binding; identical protein binding; signal transducer activity; type 5 metabotropic glutamate receptor binding; alpha-tubulin binding; tau protein binding; tau-protein kinase activity; disordered domain specific binding;
Cellular component	cytoplasm; membrane; extrinsic component of cytoplasmic side of plasma membrane; mitochondrion; nucleus; membrane raft; intracellular membrane-bounded organelle; actin filament; cell periphery; endosome; plasma membrane; cytosol; postsynaptic density; dendrite; cell body; perinuclear region of cytoplasm; perinuclear endoplasmic reticulum; glial cell projection; Schaffer collateral - CA1 synapse; glutamatergic synapse; postsynaptic density, intracellular component;
Biological process	negative regulation of neuron apoptotic process; adaptive immune response; learning; platelet activation; cell surface receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; feeding behavior; response to ethanol; calcium ion transport; regulation of apoptotic process; cellular response to transforming growth factor beta stimulus; Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of protein catabolic process; transmembrane receptor protein tyrosine kinase signaling pathway; stimulatory C-type lectin receptor signaling pathway; negative regulation of gene expression; protein autophosphorylation; T cell activation; detection of mechanical stimulus involved in sensory perception of pain; cell differentiation; dendrite morphogenesis; phosphorylation; immune system process; neuron migration; cellular response to platelet-derived growth factor stimulus; regulation of cell shape; peptidyl-tyrosine autophosphorylation; phosphatidylinositol-mediated signaling; leukocyte migration; positive regulation of protein localization to nucleus; intracellular signal transduction; activated T cell proliferation; ephrin receptor signaling pathway; cellular response to growth factor stimulus; T cell costimulation; blood coagulation; mitigation of host defenses by virus; MAPK cascade; axon guidance; multicellular organism development; negative regulation of protein ubiquitination; cellular response to peptide hormone stimulus; regulation of cell population proliferation; positive regulation of neuron projection development; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; forebrain development; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; T cell receptor signaling pathway; cell migration; viral process; innate immune response; positive regulation of GTPase activity; phosphatidylinositol phosphate biosynthetic process; regulation of phosphatidylinositol 3-kinase signaling; protein phosphorylation; central nervous system development; regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein targeting to membrane; positive regulation of neuron death; negative regulation of dendritic spine maintenance; response to amyloid-beta; regulation of calcium ion import across plasma membrane; response to singlet oxygen; heart process; negative regulation of hydrogen peroxide biosynthetic process; cytokine-mediated signaling pathway; positive regulation of tyrosine phosphorylation of STAT protein; response to hydrogen peroxide; modulation of chemical synaptic transmission; positive regulation of protein kinase B signaling; dendritic spine maintenance; regulation of glutamate receptor signaling pathway; negative regulation of oxidative stress-induced cell death; positive regulation of non-membrane spanning protein tyrosine kinase activity; cellular response to L-glutamate; cellular response to glycine; positive regulation of protein localization to membrane; positive regulation of cysteine-type endopeptidase activity; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	2534
	14360
	ENSG00000010810
	ENSMUSG00000019843
	P06241
	P39688
	NM_001242779; NM_002037; NM_153047; NM_153048; NM_001370529
	NM_001122892; NM_001122893; NM_008054
	NP_002028; NP_694592; NP_694593; NP_001357458
	NP_001116364; NP_001116365; NP_032080
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded by the FYN gene.

Fyn is a 59-kDa member of the Src family of kinases typically associated with T-cell and neuronal signaling in development and normal cell physiology. Disruptions in these signaling pathways often have implications in the formation of a variety of cancers. By definition as a proto-oncogene, Fyn codes for proteins that help regulate cell growth. Changes in its DNA sequence transform it into an oncogene that leads to the formation of a different protein with implications for normal cell regulation.

Fyn is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

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