Sodium fluoride
Sodium fluoride (NaF) is an inorganic compound with the formula NaF. It is a colorless or white solid that is readily soluble in water. It is used in trace amounts in the fluoridation of drinking water to prevent tooth decay, and in toothpastes and topical pharmaceuticals for the same purpose. In 2021, it was the 291st most commonly prescribed medication in the United States, with more than 600,000 prescriptions. It is also used in metallurgy and in medical imaging.
| Names | |
|---|---|
| Pronunciation | /ˌsoʊdiəm ˈflʊəraɪd/ |
| IUPAC name
Sodium fluoride | |
| Other names
Florocid | |
| Identifiers | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.028.789 |
| EC Number |
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| KEGG | |
PubChem CID |
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| RTECS number |
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| UNII | |
| UN number | 1690 |
CompTox Dashboard (EPA) |
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| Properties | |
| NaF | |
| Molar mass | 41.988173 g/mol |
| Appearance | White to greenish solid |
| Odor | odorless |
| Density | 2.558 g/cm3 |
| Melting point | 993 °C (1,819 °F; 1,266 K) |
| Boiling point | 1,704 °C (3,099 °F; 1,977 K) |
| 36.4 g/L (0 °C); 40.4 g/L (20 °C); 50.5 g/L (100 °C) | |
| Solubility | slightly soluble in HF, ammonia negligible in alcohol, acetone, SO2, dimethylformamide |
| Vapor pressure | 1 mmHg @ 1077 °C |
| Acidity (pKa) | 3,20 (weak base, see HF) |
| −16.4·10−6 cm3/mol | |
Refractive index (nD) |
1.3252 |
| Structure | |
| Cubic | |
a = 462 pm | |
| Octahedral | |
| Thermochemistry | |
Heat capacity (C) |
46.82 J/(mol K) |
Std molar entropy (S⦵298) |
51.3 J/(mol K) |
Std enthalpy of formation (ΔfH⦵298) |
-573.6 kJ/mol |
Gibbs free energy (ΔfG⦵) |
-543.3 kJ/mol |
| Pharmacology | |
| A01AA01 (WHO) A12CD01 (WHO), V09IX06 (WHO) (18F) | |
| Hazards | |
| GHS labelling: | |
| Danger | |
| H301, H315, H319, H335 | |
| NFPA 704 (fire diamond) | |
| Flash point | Non-flammable |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose) |
52–130 mg/kg (oral in rats, mice, rabbits) |
| NIOSH (US health exposure limits): | |
PEL (Permissible) |
TWA 2.5 mg/m3 |
REL (Recommended) |
TWA 2.5 mg/m3 |
IDLH (Immediate danger) |
250 mg/m3 (as F) |
| Safety data sheet (SDS) | |
| Related compounds | |
Other anions |
Sodium chloride Sodium bromide Sodium iodide Sodium astatide |
Other cations |
Lithium fluoride Potassium fluoride Rubidium fluoride Caesium fluoride Francium fluoride |
Related compounds |
TASF reagent |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references | |
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