Signal recognition particle receptor
Signal recognition particle (SRP) receptor, also called the docking protein, is a dimer composed of 2 different subunits that are associated exclusively with the rough ER in mammalian cells. Its main function is to identify the SRP units. SRP (signal recognition particle) is a molecule that helps the ribosome-mRNA-polypeptide complexes to settle down on the membrane of the endoplasmic reticulum.
| Signal recognition particle (SRP) receptor alpha subunit, N-terminal | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of the beta subunit of the eukaryotic signal recognition particle receptor. | |||||||||
| Identifiers | |||||||||
| Symbol | SRX | ||||||||
| Pfam | PF09201 | ||||||||
| InterPro | IPR015284 | ||||||||
| SCOP2 | 1nrj / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 136 | ||||||||
| OPM protein | 1nrj | ||||||||
| Membranome | 38 | ||||||||
| |||||||||
The eukaryotic SRP receptor (termed SR) is a heterodimer of SR-alpha (70 kDa; SRPRA) and SR-beta (25 kDa; SRPRB), both of which contain a GTP-binding domain, while the prokaryotic SRP receptor comprises only the monomeric loosely membrane-associated SR-alpha homologue FtsY (P10121).
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