SRPRB

SRPRB
Identifiers
Aliases	SRPRB, APMCF1, SRP receptor beta subunit, SRP receptor subunit beta, SR-beta
External IDs	OMIM: 616883 MGI: 102964 HomoloGene: 6332 GeneCards: SRPRB
Gene location (Human)
Chr.	Chromosome 3 (human)
End	133,825,772 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	103,079,336 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; parotid gland; ; islet of Langerhans; ; tibia; ; stromal cell of endometrium; ; periodontal fiber; ; pericardium; ; corpus epididymis; ; kidney tubule; ; trachea;
	Top expressed in
	saccule; ; otic placode; ; yolk sac; ; spermatocyte; ; renal corpuscle; ; external carotid artery; ; parotid gland; ; internal carotid artery; ; seminal vesicula; ; molar;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; signal recognition particle binding; GTP binding;
Cellular component	endoplasmic reticulum membrane; cytoplasmic microtubule; cytoplasm; integral component of membrane; signal recognition particle receptor complex; intracellular anatomical structure; endoplasmic reticulum; membrane;
Biological process	IRE1-mediated unfolded protein response;
	Sources:Amigo / QuickGO
Orthologs
	58477
	20818
	ENSG00000144867
	ENSMUSG00000032553
	Q9Y5M8
	P47758
	NM_021203; NM_001379313
	NM_009275
	NP_067026; NP_001366242
	NP_033301
	Wikidata
View/Edit Human	View/Edit Mouse

Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene.

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.

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