Separase

Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during the early stage of anaphase. In humans, separin is encoded by the ESPL1 gene.

Separase
Identifiers
EC no.3.4.22.49
CAS no.351527-77-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
ESPL1
Identifiers
AliasesESPL1, ESP1, SEPA, EPAS1, Separase, extra spindle pole bodies like 1, separase
External IDsOMIM: 604143 MGI: 2146156 HomoloGene: 32151 GeneCards: ESPL1
Orthologs
SpeciesHumanMouse
Entrez

9700

105988

Ensembl

ENSG00000135476

ENSMUSG00000058290

UniProt

Q14674

P60330

RefSeq (mRNA)

NM_012291

NM_001014976
NM_001356312

RefSeq (protein)

NP_036423

NP_001014976
NP_001343241

Location (UCSC)Chr 12: 53.27 – 53.29 MbChr 15: 102.2 – 102.23 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.